ArticleGenetics1997
stand still, a Drosophila gene involved in the female germline for proper survival, sex determination and differentiation.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Transcriptional repression of reaper by Stand still ensures female germline development in Drosophila.PLoS genetics · 2026Article
- AnOpen biology · 2017Article
- Article
- The establishment of sexual identity in the Drosophila germline.Development (Cambridge, England) · 2009Article
- Drosophila germline sex determination: integration of germline autonomous cues and somatic signals.Current topics in developmental biology · 2008Article
- A survey of ovary-, testis-, and soma-biased gene expression in Drosophila melanogaster adults.Genome biology · 2004Article
- Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins.Genetics · 2000Article
- Multiple developmental requirements of noisette, the Drosophila homolog of the U2 snRNP-associated polypeptide SP3a60.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We identified a new gene, stand still (stil), required in the female germline for proper survival, sex determination and differentiation. Three strong loss-of-function alleles were isolated. The strongest phenotype exhibited by ovaries dissected from adult females is the complete absence of germ cells. In other ovaries, the few surviving germ cells frequently show a morphology typical of primary spermatocytes. stil is not required either for fly viability or for male germline development. The gene was cloned and found to encode a novel protein. stil is strongly expressed in the female germ cells. Using P[stil+] transgenes, we show that stil and a closely localized gene are involved in the modification of the ovarian phenotypes of the dominant alleles of ovo caused by heterozygosity of region 49 A-D. The similarity of the mutant phenotypes of stil to that of otu and ovo suggests that the three genes function in a common or in parallel pathways necessary in the female germline for its survival, sex determination and differentiation.
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