Evidence map›Paper›PMID 9093846›Full record

ArticleGenetics1997

Increased length of long terminal repeats inhibits Ty1 transposition and leads to the formation of tandem multimers.

V Lauermann, M Hermankova, J D Boeke

Abstract read
In one paragraph

Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Progresses of transposon research inSynthetic and systems biotechnology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

V LauermannDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
M Hermankova
J D Boeke

Funding

TRANSPOSITION MECHANISMSR01GM036481 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BOEKE, JEF D · 1986 to 2011
$5.6M
NCI NIH HHS CA-16319NIGMS NIH HHS GM-36481
6 · The paper itself

Abstract

The Ty1 retrotransposon of Saccharomyces cerevisiae is bounded by long-terminal repeats (LTRs). We have constructed a variety of Ty1 elements in which the LTR length has been increased from the normal length of 334 bp to > 2 kb. Although small insertions in the LTR have minimal effects on transposition frequency, larger insertions dramatically reduce it. Nevertheless, elements with long LTRs are incorporated into the genome at a low frequency. Most of these rare insertion events represent Ty1 tandem (head to tail) multimers.

Indexed as

Repetitive Sequences, Nucleic AcidDNA-Binding ProteinsDNA, FungalFungal ProteinsMutagenesis, InsertionalPlasmidsRad52 DNA Repair and Recombination ProteinRetroelementsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDNA-Binding ProteinsDNA, FungalFungal ProteinsRad52 DNA Repair and Recombination ProteinRAD52 protein, S cerevisiaeRetroelementsSaccharomyces cerevisiae Proteins

Identifiers

PMID9093846
PMCPMC1207896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.