ArticleThorax1997
Epithelial barrier formation by airway basal cells.
Article in Thorax, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Supportive fibrous tissues of the nasal epithelium with special reference to the site-dependent difference.Anatomy & cell biology · 2026Article
- Cloned airway basal progenitor cells to repair fibrotic lung through re-epithelialization.Nature communications · 2025Article
- The epithelial barrier: a Janus-faced regulator in allergic airway diseases from defense to inflammation.Frontiers in allergy · 2025Review
- Quantification of basal stem cell elongation and stress fiber accumulation in the pseudostratified airway epithelium during the unjamming transition.Biology open · 2023Article
- Development and characterization of ferretFrontiers in medicine · 2023Article
- Epithelial-Cell-Derived Extracellular Vesicles in Pathophysiology of Epithelial Injury and Repair in Chronic Rhinosinusitis: Connecting Immunology in Research Lab to Biomarkers in Clinics.International journal of molecular sciences · 2021Review
- Airways exudation of plasma macromolecules: Innate defense, epithelial regeneration, and asthma.The Journal of allergy and clinical immunology · 2019Review
- Chemokine expression in the early response to injury in human airway epithelial cells.PloS one · 2018Article
- Cigarette Smoke Modulates Repair and Innate Immunity following Injury to Airway Epithelial Cells.PloS one · 2016Article
- Isolated Rat Epididymal Basal Cells Share Common Properties with Adult Stem Cells.Biology of reproduction · 2015Article
- D prostanoid receptor 2 (chemoattractant receptor-homologous molecule expressed on TH2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells.The Journal of allergy and clinical immunology · 2015Article
- Fluticasone Induces Epithelial Injury and Alters Barrier Function in Normal Subjects.Journal of steroids & hormonal science · 2014Article
- The human airway epithelial basal cell transcriptome.PloS one · 2011Article
- Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium.American journal of respiratory and critical care medicine · 2010Article
- Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Interleukin-1beta mediates human airway epithelial cell migration via NF-kappaB.American journal of physiology. Lung cellular and molecular physiology · 2008Article
- Glucocorticoids increase repair potential in a novel in vitro human airway epithelial wounding model.Journal of clinical immunology · 2006Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpithelial shedding processes in airway inflammation and defence may produce damaged areas where basal cells are the main remaining epithelial cell type. The present study examines the capacity of basal cells to form an epithelial barrier structure after loss of columnar epithelial cells.
methodsA technique was developed which allows selective removal of columnar epithelial cells from isolated airways. A drop of tissue adhesive glue was applied on the mucosal surface shortly after excision of guinea pig trachea and human bronchus. Gentle removal of the glue, together with attached columnar cells, left a single layer of cobbled, solitary basal cells. The tissue was kept in culture media. Morphological changes of the basal cells were monitored by immuno-histochemistry and scanning and transmission electron microscopy at several time points.
resultsAfter 20 minutes the basal cells had undergone extensive flattening and established contact with each other. The basement membrane thus became covered by a poorly differentiated epithelium in both guinea pig and human airways. Abundant interdigitating cytoplasmic protrusions were observed at cell borders.
conclusionsBasal cells promptly flatten out to cover the basement membrane at loss of neighbouring columnar cells. These data may explain why the epithelial barrier function may be uncompromised in desquamative airway diseases. Furthermore, they suggest the possibility that sacrificial release of columnar epithelial cells and prompt creation of a barrier structure constitute important roles of basal cells in airway defence against severe insults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.