ArticleNucleic acids research1997
Adjacent GATA and kappa B-like motifs regulate the expression of a Drosophila immune gene.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 86 citations in OpenAlex.
- Atg8 orchestrates stress-responsive chromatin programs across immunity and metabolism.bioRxiv : the preprint server for biology · 2026Article
- Heterogeneous NF-κB activation and enhancer features shape transcription in Drosophila immunity.Biophysical journal · 2026Article
- BmNPV interacts with super-enhancer regions of the host chromatin to hijack cellular transcription machinery.Nucleic acids research · 2025Article
- The evolutionary novelty of insect defensins: from bacterial killing to toxin neutralization.Cellular and molecular life sciences : CMLS · 2024Article
- Viruses and antiviral immunity in Drosophila.Developmental and comparative immunology · 2014Review
- The shrimp IKK-NF-κB signaling pathway regulates antimicrobial peptide expression and may be subverted by white spot syndrome virus to facilitate viral gene expression.Cellular & molecular immunology · 2013Article
- Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity.The EMBO journal · 2013Article
- Immune response in the barrier epithelia: lessons from the fruit fly Drosophila melanogaster.Journal of innate immunity · 2012Review
- Manduca sexta moricin promoter elements can increase promoter activities of Drosophila melanogaster antimicrobial peptide genes.Insect biochemistry and molecular biology · 2011Article
- Identification, phylogenetic analysis and expression profile of an anionic insect defensin gene, with antibacterial activity, from bacterial-challenged cotton leafworm, Spodoptera littoralis.BMC molecular biology · 2011Article
- Article
- NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster.Current topics in microbiology and immunology · 2011Review
- The POU transcription factor Drifter/Ventral veinless regulates expression of Drosophila immune defense genes.Molecular and cellular biology · 2010Article
- Sequence structure and expression pattern of a novel anionic defensin-like gene from silkworm (Bombyx mori).Molecular biology reports · 2009Article
- Gene expression divergence and evolutionary analysis of the drosomycin gene family in Drosophila melanogaster.Journal of biomedicine & biotechnology · 2009Article
- Immunity related genes in dipterans share common enrichment of AT-rich motifs in their 5' regulatory regions that are potentially involved in nucleosome formation.BMC genomics · 2008Article
- DEAF-1 regulates immunity gene expression in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- The malaria vector mosquito Anopheles gambiae expresses a suite of larval-specific defensin genes.Insect molecular biology · 2008Article
- A kappaB sequence code for pathway-specific innate immune responses.The EMBO journal · 2007Article
- A novel association between clustered NF-kappaB and C/EBP binding sites is required for immune regulation of mosquito Defensin genes.Insect molecular biology · 2006Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The GATA motif is a well known positive cis -regulatory element in vertebrates. In this work we report experimental evidence for the direct participation of a GATA motif in the expression of the Drosophila antibacterial peptide gene Cecropin A1 . Previously we have shown that a kappaB-like site is necessary for Cecropin A1 gene expression. Here we present evidence that the Drosophila Rel protein which binds to the kappaB-like site requires an intact GATA site for maximal Dif-mediated transactivation of the Cecropin A1 gene. We show that a Drosophila blood cell line contains factors binding specifically to the GATA motif of the Cecropin A1 gene. The GATA binding activity is likely to include member(s) of the GATA family of transcriptional regulators. We show that the promoters of several inducible insect immune genes possess GATA sites 0-12 base pairs away from kappaB-like sites in functionally important promoter regions. Clusters of GATA and kappaB sites are also observed in the promoters of two important mammalian immune genes, namely IL6 and IL3. The consistent proximity of GATA and kappaB sites appears to be a common theme in the immune gene expression of insects and mammals.
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