ArticleNucleic acids research1997
Isolation and characterization of the human nucleophosmin/B23 (NPM) gene: identification of the YY1 binding site at the 5' enhancer region.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 49 citations in OpenAlex.
- mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation.Cell cycle (Georgetown, Tex.) · 2016Article
- Phosphorylated STAT3 physically interacts with NPM and transcriptionally enhances its expression in cancer.Oncogene · 2015Article
- TPL2 kinase is a suppressor of lung carcinogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription.Retrovirology · 2008Article
- TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation.Cancer research · 2007Article
- Article
- cDNA microarray analysis of bovine embryo gene expression profiles during the pre-implantation period.Reproductive biology and endocrinology : RB&E · 2004Article
- Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter.Molecular and cellular biology · 2004Article
- Article
- Vav-promoter regulated oncogenic fusion protein NPM-ALK in transgenic mice causes B-cell lymphomas with hyperactive Jun kinase.Oncogene · 2003Article
- Conventional and nonconventional roles of the nucleolus.International review of cytology · 2002Review
- Review
- Translocations involving anaplastic lymphoma kinase (ALK).Oncogene · 2001Review
- Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas.Leukemia · 2000Review
- ALK expression defines a distinct group of T/null lymphomas ("ALK lymphomas") with a wide morphological spectrum.The American journal of pathology · 1998Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
NPM (nucleophosmin/B23) is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. Recently, it was found that NPM gene is located at the breakpoints of the t(2:5), t(3:5) and t(5:17) chromosome translocation. To understand the human NPM gene's structure and regulation, four genomic clones were isolated from the human chromosome 5 library and their DNA sequences analyzed. The human NPM gene has 12 exons of sizes ranging from 58 to 358 bp. The chromosome breakpoint for t(2:5) and t(5:17) translocation is within intron 4 and the breakpoint for t(3:5) translocation is within intron 6. The initiation site is located 96 bp upstream from the ATG site. A typical TATA box (at -25 nt) and a GC box (at -65 nt) were identified in the promoter region. We identified two gel-shift bands (A and B) with DNA fragment E (-741/-250 nt) by EMSA. A DNA footprint was observed at (-371/-344 nt) with the nuclear extract. A double stranded DNA with the footprint sequence (-371/-344 nt) competed the formation of gel-shift bands A and B in EMSA suggesting that proteins A and B bind to the footprint region. We confirmed that protein A is transcription factor YY1. These results suggest that YY1 may play a role in NPM gene expression. This is the first report on human NPM gene structure and sequence.
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