ArticleNucleic acids research1997
Characterisation of Schizosaccharomyces pombe rad31, a UBA-related gene required for DNA damage tolerance.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- SUMOylation is required for fungal development and pathogenicity in the rice blast fungus Magnaporthe oryzae.Molecular plant pathology · 2018Article
- SUMO and the robustness of cancer.Nature reviews. Cancer · 2017Review
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- The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2.PloS one · 2014Article
- SUMOylation in control of accurate chromosome segregation during mitosis.Current protein & peptide science · 2012Review
- Rod/Zw10 complex is required for PIASy-dependent centromeric SUMOylation.The Journal of biological chemistry · 2010Article
- NMR metabolomic profiling reveals new roles of SUMOylation in DNA damage response.Journal of proteome research · 2010Article
- Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9.The Journal of biological chemistry · 2010Article
- The SUMO pathway functions in mouse oocyte maturation.Cell cycle (Georgetown, Tex.) · 2010Article
- Article
- Article
- Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation.PloS one · 2009Article
- Emerging roles of the SUMO pathway in mitosis.Cell division · 2008Article
- Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins.The EMBO journal · 2007Article
- Genetic analysis of SUMOylation in Arabidopsis: conjugation of SUMO1 and SUMO2 to nuclear proteins is essential.Plant physiology · 2007Article
- The role of SUMO in chromosome segregation.Chromosoma · 2007Review
- Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage.Molecular and cellular biology · 2005Article
- Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance.The EMBO journal · 2004Article
- SUMO-2/3 regulates topoisomerase II in mitosis.The Journal of cell biology · 2003Article
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Authors and funding
4 authors.
Funding
Abstract
The fission yeast rad31-1 mutant is sensitive to both UV and ionising radiation and exhibits a growth defect at 35 degrees C. In addition, the mutant displays defects in cell morphology and nuclear division at 26 degrees C which are exaggerated at 35 degrees C. We have cloned the rad31 gene and have shown that it is not essential for viability, although cells containing a disrupted rad31 gene grow slowly. The null allele has similar cell and nuclear morphologies to the original allele and displays an extremely high frequency of loss of minichromosomes. rad31 is not required for either the S/M or G2/M checkpoint, however double mutant analysis indicates that rad31 acts in a process which is defective in the checkpoint rad mutants and which involves hus5 . Sequence analysis indicates that rad31 encodes a protein which is related to ubiquitin activating proteins and more particularly to an ORF in Saccharomyces cerevisiae and to the Arabidopsis thaliana AXR1 and human APP-BP1 genes. We have isolated the S.cerevisiae sequence, which we have named RHC31 ( ad31homologue in S. erevisiae), since we show that it can complement the slow growth phenotype and radiation sensitivity of S.pombe rad31.
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