ArticleNucleic acids research1997
The ZiN/POZ domain of ZF5 is required for both transcriptional activation and repression.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 79 citations in OpenAlex.
- A dynamic gene regulatory code drives synaptic development of hippocampal granule cells.Science advances · 2025Article
- ZFP161 promotes colorectal cancer progression by transcriptionally activating c-MYC.Frontiers in oncology · 2025Article
- SUMOylation of zebrafish transcription factor Zbtb21 affects its transcription activity.PeerJ · 2024Article
- Bioinformatics analysis and the association of polymorphisms within the caprineAnimal biotechnology · 2023Article
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- Meta-Analysis of Transcriptome Data Detected New Potential Players in Response to Dioxin Exposure in Humans.International journal of molecular sciences · 2020Article
- Effects of Naturally Occurring Mutations in Bovine Leukemia Virus 5'-LTR and Tax Gene on Viral Transcriptional Activity.Pathogens (Basel, Switzerland) · 2020Article
- Expression characterization and transcription regulation analysis of porcine Yip1 domain family member 3 gene.Asian-Australasian journal of animal sciences · 2020Article
- ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex.Nature communications · 2019Article
- Kaiso protects human umbilical vein endothelial cells against apoptosis by differentially regulating the expression of B-cell CLL/lymphoma 2 family members.Scientific reports · 2017Article
- Contrasting expression patterns of coding and noncoding parts of the human genome upon oxidative stress.Scientific reports · 2015Article
- Beta-Actin Is Involved in Modulating Erythropoiesis during Development by Fine-Tuning Gata2 Expression Levels.PloS one · 2013Article
- New polymorphisms in human MEF2C gene as potential modifier of hypertrophic cardiomyopathy.Molecular biology reports · 2012Article
- Loss, mutation and deregulation of L3MBTL4 in breast cancers.Molecular cancer · 2010Article
- Regulation of the mouse Treacher Collins syndrome homolog (Tcof1) promoter through differential repression of constitutive expression.DNA and cell biology · 2008Article
- Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: identification of the c-myc regulatory gene network.BMC systems biology · 2008Article
- Prediction of synergistic transcription factors by function conservation.Genome biology · 2007Article
- Article
- ZENON, a novel POZ Kruppel-like DNA binding protein associated with differentiation and/or survival of late postmitotic neurons.Molecular and cellular biology · 2005Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ZF5 is a ubiquitously expressed protein originally identified by its ability to bind and repress the murine c-myc promoter. It contains five C-terminal zinc fingers and a conserved N-terminal ZiN/POZ domain. This motif, found in a growing number of zinc finger proteins, can inhibit DNA binding and mediate dimerization [Bardwell, V.J. and Treisman,R. (1994) Genes Dev., 8,1664-1677]. In the current study, a cyclic amplification and selection of targets (CAST) protocol detected preferred ZF5 binding sites which are highly GC-rich. Binding to these sites by ZF5 depended upon the zinc fingers and was enhanced when the ZiN/POZ domain was removed. Using transient cotransfection assays, ZF5 was shown to activate the HIV-1 LTR and repress the beta-actin promoter. The ZiN/POZ domain was shown to mediate ZF5-dependent transcriptional activation and repression. From these data, we conclude that ZF5 can both activate and repress in the context of different natural promoters and that its ZiN/POZ domain can affect two functions; DNA binding and transcriptional modulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.