ArticleNucleic acids research1997
Parallel-stranded linear homoduplexes of d(A+-G)n > 10 and d(A-G)n > 10 manifesting the contrasting ionic strength sensitivities of poly(A+.A+) and DNA.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Switching G-quadruplex to parallel duplex by molecular rotor clustering.Nucleic acids research · 2022Article
- Sequence-specific recognition of a coding segment of humanRSC advances · 2021Article
- Revealing structural peculiarities of homopurine GA repetition stuck by i-motif clip.Nucleic acids research · 2021Article
- Thioflavin T binds dimeric parallel-stranded GA-containing non-G-quadruplex DNAs: a general approach to lighting up double-stranded scaffolds.Nucleic acids research · 2017Article
- A bouquet of DNA structures: Emerging diversity.Biochemistry and biophysics reports · 2016Review
- Circular dichroism and conformational polymorphism of DNA.Nucleic acids research · 2009Review
- Are stop codons recognized by base triplets in the large ribosomal RNA subunit?RNA (New York, N.Y.) · 2005Article
- NMR structure of a parallel-stranded DNA duplex at atomic resolution.Nucleic acids research · 2002Article
- Conformational properties of DNA strands containing guanine-adenine and thymine-adenine repeats.Nucleic acids research · 1998Article
- Effect of the 1-(2'-deoxy-beta-D-ribofuranosyl)-3-nitropyrrole residue on the stability of DNA duplexes and triplexes.Nucleic acids research · 1997Article
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3 authors.
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Abstract
In contrast to shorter homologs which only form a single-stranded nucleic acid alpha-helix in acid solution at [Na+]</=0.02 M Na+, d(A-G)20,30 form in addition a parallel-stranded duplex with (A+.A+) and (G.G) base pairs and interstrand dA+...PO2-ionic and dA+NH2... O=P H-bonds. Under conditions where duplex prevails over alpha-helix, the contribution of the base-backbone interactions to stability varies directly with [H+] and inversely with [Na+], just as in poly(A+.A+). These duplexes are characterized by intense circular dichroism and a large cooperative thermally-induced hyperchromic transition that is dependent on oligomer concentration. Dimethylsulfate reactivity of the dG residues indicates G.G and therefore dA+.dA+rather than dA+.G base pairs. At much higher ionic strength (Na+>/=0.2 M) the protonated base-backbone interactions are so weakened that duplex stability becomes increasingly dependent upon H-bonded base pairing and stacking and almost independent of pH. Between pH 6 and 8 this duplex structure is devoid of protonated dA residues and shows positive dependence of T m on ionic strength similar to that of DNA.
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