ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Selective alteration of long-term potentiation-induced transcriptional response in hippocampus of aged, memory-impaired rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 88 citations in OpenAlex.
- Memory-Associated Immediate Early Genes: Roles in Synaptic Function, Memory Processes, and Neurological Diseases.Molecular neurobiology · 2025Review
- Altered NPTX2 dynamics associated with impaired cognitive aging.bioRxiv : the preprint server for biology · 2025Article
- A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function.Science advances · 2021Article
- Age-Related Memory Impairment Is Associated with Increased zif268 Protein Accumulation and Decreased Rpt6 Phosphorylation.International journal of molecular sciences · 2020Article
- Across sex and age: Learning and memory and patterns of avian hippocampal gene expression.Behavioral neuroscience · 2017Article
- Exercise Counteracts Aging-Related Memory Impairment: A Potential Role for the Astrocytic Metabolic Shuttle.Frontiers in aging neuroscience · 2016Review
- Spatial behavior and seizure-induced changes in c-fos mRNA expression in young and old rats.Neurobiology of aging · 2013Article
- Long-term decrease in immediate early gene expression after electroconvulsive seizures.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Assessment of spatial memory in mice.Life sciences · 2010Review
- Neural Protein Synthesis during Aging: Effects on Plasticity and Memory.Frontiers in aging neuroscience · 2010Article
- Amyloid-β as a modulator of synaptic plasticity.Journal of Alzheimer's disease : JAD · 2010Review
- Region-specific genetic alterations in the aging hippocampus: implications for cognitive aging.Frontiers in aging neuroscience · 2010Article
- Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase.PloS one · 2009Article
- Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia.Frontiers in integrative neuroscience · 2007Article
- The in vivo synaptic plasticity mechanism of EGb 761-induced enhancement of spatial learning and memory in aged rats.British journal of pharmacology · 2006Article
- Nonpharmacological amelioration of age-related learning deficits: the impact of hippocampal theta-triggered training.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Long-term potentiation is impaired in middle-aged rats: regional specificity and reversal by adenosine receptor antagonists.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Aging impairs the late phase of long-term potentiation at the medial perforant path-CA3 synapse in awake rats.Synapse (New York, N.Y.) · 2004Article
- Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Normal human aging is associated with selective changes in cognition that are attributable, in part, to dysfunction of hippocampal pathways. Rodents also exhibit age-dependent hippocampal dysfunction that results in spatial memory deficits and a correlated reduction in the maintenance of long-term potentiation (LTP). Although suprathreshold stimulus protocols result in normal LTP induction in aged rats, the ability to sustain this increase in synaptic efficacy is reduced in the old animals. The maintenance phase of LTP is known to be dependent on rapid, transcriptional events, and recent studies have identified signal transduction mechanisms that link glutamate-induced responses at the synapse with transcriptional responses at the nucleus. To examine the integrity of these signaling pathways in aged hippocampus, we monitored the induction of a panel of immediate early genes (IEGs) that are known to be transcriptionally activated after LTP-inducing stimuli, using a "reverse Northern" strategy. Here we report that a broad representation of IEGs are similarly induced in awake, behaving young adult and aged, memory-impaired rats. This indicates a general preservation of these presumptive signaling pathways during the aging process. Induced levels of c-fos mRNA, however, are significantly higher in the aged animals. These observations suggest that age-dependent hippocampal dysfunction may be associated with a selective change in the dynamic activity of signaling pathways upstream of c-fos, possibly involving calcium regulation.
Indexed as
Identifiers
9092609PMC6573119W2104029934What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.