ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Identification of a long-lasting form of odor adaptation that depends on the carbon Monoxide/cGMP second-messenger system.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 96 citations in OpenAlex.
- The role of the odorant receptors in the formation of the sensory map.BMC biology · 2021Review
- Interhemispheric asymmetry of c-Fos expression in glomeruli and the olfactory tubercle following repeated odor stimulation.FEBS open bio · 2020Article
- Carbon monoxide modulates electrical activity of murine myocardium via cGMP-dependent mechanisms.Journal of physiology and biochemistry · 2015Article
- Habituation of glomerular responses in the olfactory bulb following prolonged odor stimulation reflects reduced peripheral input.Frontiers in molecular neuroscience · 2015Article
- Modulation of sinoatrial node pacemaker activity by carbon monoxide and hydrogen sulfide.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2013Article
- Calcium-stores mediate adaptation in axon terminals of olfactory receptor neurons in Drosophila.BMC neuroscience · 2011Article
- Carbon monoxide affects electrical and contractile activity of rat myocardium.Journal of biomedical science · 2011Article
- Interplay among cGMP, cAMP, and Ca2+ in living olfactory sensory neurons in vitro and in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- A 3'UTR pumilio-binding element directs translational activation in olfactory sensory neurons.Neuron · 2009Article
- Odorant responses of olfactory sensory neurons expressing the odorant receptor MOR23: a patch clamp analysis in gene-targeted mice.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Presence of long-lasting peripheral adaptation in oblique-banded leafroller, Choristoneura rosaceana and absence of such adaptation in redbanded leafroller, Argyrotaenia velutinana.Journal of chemical ecology · 2003Article
- Heme oxygenase-2 and nitric oxide synthase immunoreactivity of bovine olfactory receptor neurons and a comparison with the distribution of NADPH-diaphorase staining.The Histochemical journal · 2000Article
- Odorants induce the phosphorylation of the cAMP response element binding protein in olfactory receptor neurons.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Adaptation of the odour-induced response in frog olfactory receptor cells.The Journal of physiology · 1999Article
- Olfactory adaptation depends on the Trp Ca2+ channel in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Imaging odor-induced calcium transients in single olfactory cilia: specificity of activation and role in transduction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Heme oxygenase 1 is required for mammalian iron reutilization.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Calcium entry through cyclic nucleotide-gated channels in individual cilia of olfactory receptor cells: spatiotemporal dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Presynaptic effects of carbon monoxide in the myoneural synapse of the frog.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sectionsArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The diffusible messenger carbon monoxide (CO) has been proposed to mediate endogenous cyclic guanosine 3',5'-monophosphate (cGMP) formation and sensory adaptation in vertebrate olfactory receptor neurons (ORNs). We have identified and characterized a long-lasting form of odor response adaptation (LLA) that operates at the level of isolated salamander ORNs and does not require any interactions from other cells. Manifestations of LLA are seen in reduced amplitude and prolonged kinetics of the cAMP-mediated excitatory odor response and the generation of a persistent current component that lasts for several minutes and is attributable to cyclic nucleotide-gated (CNG) channel activation by cGMP. Because these effects can be mimicked by micromolar amounts of exogenous cGMP or CO, we applied various inhibitors of cGMP formation. LLA is abolished selectively by heme oxygenase inhibitors known to prevent CO release and cGMP formation in ORNs, whereas odor excitation remains unaffected. In contrast, blockers of nitric oxide synthase are unable to eliminate LLA. Several controls rule out a contribution of nonspecific actions to the effects of CO inhibitors. The results indicate that endogenous CO/cGMP signals contribute to olfactory adaptation and underlie the control of gain and sensitivity of odor transduction. The findings offer a mechanism by which a single, brief odor stimulus can be translated into long-lasting intracellular changes that could play an important role in the perceptual adaptation to odors, and explain the longstanding puzzle that the olfactory CNG channels can be gated by both cAMP and cGMP.
Indexed as
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9092591PMC6573108W1595603700What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.