ArticleChromosoma1997
Association of the neuron-specific RNA binding domain-containing protein ELAV with the coiled body in Drosophila neurons.
Article in Chromosoma, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Phylogenomic instructed target analysis reveals ELAV complex binding to multiple optimally spaced U-rich motifs.Nucleic acids research · 2024Article
- A conserved nutrient responsive axis mediates autophagic degradation of miRNA-mRNA hybrids in blood cell progenitors.Nucleic acids research · 2024Article
- Article
- Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation.eLife · 2022Article
- Cajal bodies and their role in plant stress and disease responses.RNA biology · 2017Review
- Article
- Genetic analysis of nuclear bodies: from nondeterministic chaos to deterministic order.Cold Spring Harbor symposia on quantitative biology · 2010Article
- snRNP: Rich Nuclear Bodies in Hyacinthus orientalis L. Microspores and Developing Pollen Cells.International journal of cell biology · 2009Article
- The Drosophila melanogaster Cajal body.The Journal of cell biology · 2006Article
- Cell cycle-regulated trafficking of human telomerase to telomeres.Molecular biology of the cell · 2006Article
- ELAV multimerizes on conserved AU4-6 motifs important for ewg splicing regulation.Molecular and cellular biology · 2005Article
- Article
- A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin.BMC cell biology · 2005Article
- A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs.The EMBO journal · 2003Article
- The neuron-specific RNA-binding protein ELAV regulates neuroglian alternative splicing in neurons and binds directly to its pre-mRNA.Genes & development · 2001Article
- Box C/D small nucleolar RNA trafficking involves small nucleolar RNP proteins, nucleolar factors and a novel nuclear domain.The EMBO journal · 2001Article
- Human Slug is a repressor that localizes to sites of active transcription.Molecular and cellular biology · 2000Article
- Article
- Nuclear domains enriched in RNA 3'-processing factors associate with coiled bodies and histone genes in a cell cycle-dependent manner.Molecular biology of the cell · 1999Article
- Analysis of the functional specificity of RS domains in vivo.The EMBO journal · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The subcellular distribution of the Drosophila nervous system-specific RNA binding domain-containing protein ELAV was investigated using ELAV-specific antibodies and scanning confocal laser microscopy. ELAV is predominantly localized within the nucleus where it concentrates within discrete domains we describe as dots and webs. To characterize these discrete domains an analysis of Drosophila coiled bodies was initiated. The polyclonal antibody R288 raised against human coilin was used to identify coiled bodies in cells of the Drosophila larval central nervous system. Double-labeling immunohistochemistry showed that, similar to vertebrate and plant systems, small nuclear ribonucleoproteins are enriched within these structures. Further analysis of ELAV revealed that subnuclear domains enriched with this molecule localize within and close to coiled bodies and close to subnuclear domains enriched with splicing factors. A preliminary analysis aimed at defining a region within ELAV that may mediate a molecular or functional interaction important for its subnuclear localization revealed that deletion of the ELAV alanine/glutamine-rich amino-terminal auxiliary domain has no discernible effect on localization and that proteins produced from elav lethal alleles distribute normally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.