ReviewClinical pharmacokinetics1997
Target concentration strategy for cyclosporin monitoring.
Review in Clinical pharmacokinetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Optimizing Mycophenolic Acid Exposure in Kidney Transplant Recipients: Time for Target Concentration Intervention.Transplantation · 2019Review
- Bayesian estimation of cyclosporin exposure for routine therapeutic drug monitoring in kidney transplant patients.British journal of clinical pharmacology · 2005Article
- Immunosuppressive therapy for paediatric transplant patients: pharmacokinetic considerations.Clinical pharmacokinetics · 2002Review
- Methods for clinical monitoring of cyclosporin in transplant patients.Clinical pharmacokinetics · 2000Review
- Target concentration intervention: beyond Y2K.British journal of clinical pharmacology · 1999Article
- Therapeutic drug monitoring of immunosuppressant drugs.British journal of clinical pharmacology · 1999Review
- Clinical pharmacokinetics in the 21st century. Does the evidence support definitive outcomes?Clinical pharmacokinetics · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The target concentration concept has been proposed as a potential alternative to the established, and probably much abused, therapeutic range method of interpreting concentrations of therapeutic drugs in plasma, serum or blood when individualising drug dosages. This paper raises for debate the possibility of extending this alternative concept to immunosuppressant monitoring with cyclosporin, where there has been considerable difficulty in establishing therapeutic ranges which are widely accepted and applied. In its broader application, the target concentration strategy does present advantage to the clinician in precision, ability to calculate the dose directly from the target concentration and clearance, as well as a clearer concept of an optimal concentration (differentiating desired and adverse effects).
Indexed as
Identifiers
9084957What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.