ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery1997
Anaplastic pleomorphic xanthoastrocytoma.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 56 citations in OpenAlex.
- PXA-like tumors: prognostic implications.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Drug-resistant schizophrenia-like psychosis associated with temporal non-anaplastic pleomorphic xanthoastrocytoma: unusual revealing symptom of a rare pathology.Annals of medicine and surgery (2012) · 2024Article
- Clinical features and surgical outcomes of high grade pleomorphic xanthoastrocytomas: a single-center experience with a systematic review.Frontiers in oncology · 2023Article
- Pleomorphic xanthoastrocytoma in the multiverse of epigenomics: is it time to recognize the variants?Acta neuropathologica communications · 2022Article
- Gene expression based profiling of pleomorphic xanthoastrocytoma highlights two prognostic subgroups.American journal of translational research · 2022Article
- Evaluating Surgical Resection Extent and Adjuvant Therapy in the Management of Gliosarcoma.Frontiers in oncology · 2020Article
- Pleomorphic xanthoastrocytoma: a brief review.CNS oncology · 2019Review
- Demography, Pattern of Care, and Survival in Patients with Xanthoastrocytoma: A Systematic Review and Individual Patient Data Analysis of 325 Cases.Journal of neurosciences in rural practice · 2019Article
- A rare clinical presentation: a pleomorphic xanthoastrocytoma presenting with intracerebral haemorrhage and metastasizing vigorously-case report and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Review
- Aggressive behavior and anaplasia in pleomorphic xanthoastrocytoma: a plea for a revision of the current WHO classification.CNS oncology · 2013Review
- Anaplastic PXA in adults: case series with clinicopathologic and molecular features.Journal of neuro-oncology · 2013Article
- Long-term epilepsy-associated tumors.Brain pathology (Zurich, Switzerland) · 2012Review
- Pleomorphic xanthoastrocytoma with malignant transformation and multiple recurrences in an Iranian girl.BMJ case reports · 2012Article
- Neuropathology of temporal lobe epilepsy.Epilepsy research and treatment · 2012Article
- Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation.Neuro-oncology · 2009Article
- Pleomorphic xanthoastrocytomas: immunohistochemistry, grading and clinico-pathologic correlations. An analysis of 34 cases from a single Institute.Journal of neuro-oncology · 2001Article
- Does the occurrence of pleomorphic xanthoastrocytoma in the elderly carries a poor prognosis: A case report and review of literature.Asian journal of neurosurgeryArticle
- Pleomorphic xanthoastrocytoma with anaplastic features: A rare case report and review of literature with reference to current management.Asian journal of neurosurgeryArticle
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A case of anaplastic pleomorphic xanthoastrocytoma (PXA) in a 9-year-old girl is reported. Histological features of PXAs are cellular pleomorphism of GFAP-positive cells, with intracytoplasmic lipidic vacuoles and a reticulin network, bizarre giant cells, low mitotic activity, and lack of necrosis and of endothelial vascular proliferations. These tumors are generally reported to have a favorable postoperative course. In our case, a poor clinical prognosis and spread of the illness through the CSF was observed. Immunohistochemical features of the tumor, which were histologically anaplastic in nature, were analyzed. There were small foci of necrosis in the sections of the material obtained at the first operation and extensive necrosis in that from the second operation, although the patient had not received radiotherapy between the operations. The presence of necrosis in PXA is an uncommon and significant feature. It predicts the poor prognosis seen in this case, and therefore this report strongly supports the notion that necrosis should automatically exclude a tumor from the PXA category. The histological grade was evaluated as grade 3 (according to the WHO classification).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.