ArticleBiophysical journal1997
Synaptic transmission at visualized sympathetic boutons: stochastic interaction between acetylcholine and its receptors.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- Alternative Pathways of Acetylcholine Release in the Colon: Role of High-Affinity Choline Transporters.Neurogastroenterology and motility · 2026Article
- Mechanisms of stationary voltage fluctuation in the neuromuscular junction endplate and corresponding denoising paradigms.European biophysics journal : EBJ · 2024Article
- Mechanisms shaping the slow nicotinic synaptic current at the motoneuron-renshaw cell synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The neuronal nicotinic alpha4beta2 receptor has a high maximal probability of being open.British journal of pharmacology · 2010Article
- Evidence for ectopic neurotransmission at a neuronal synapse.Science (New York, N.Y.) · 2005Article
- Quantal and non-quantal current and potential fields around individual sympathetic varicosities on release of ATP.Biophysical journal · 2001Article
- The probability of quantal secretion near a single calcium channel of an active zone.Biophysical journal · 2000Article
- Quantal potential fields around individual active zones of amphibian motor-nerve terminals.Biophysical journal · 2000Article
- Analysis of synaptic transmission in the neuromuscular junction using a continuum finite element model.Biophysical journal · 1998Article
- On the origin of skewed distributions of spontaneous synaptic potentials in autonomic ganglia.Proceedings. Biological sciences · 1998Article
- Probabilistic secretion of quanta and the synaptosecretosome hypothesis: evoked release at active zones of varicosities, boutons, and endplates.Biophysical journal · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excitatory postsynaptic currents (EPSCs) were recorded with loose patch electrodes placed over visualized boutons on the surface of rat pelvic ganglion cells. At 34 degrees C the time to peak of the EPSC was about 0.7 ms, and a single exponential described the declining phase with a time constant of about 4.0 ms; these times were not correlated with changes in the amplitude of the EPSC. The amplitude-frequency histogram of the EPSC at individual boutons was well described by a single Gaussian-distribution that possessed a variance similar to that of the electrical noise. Nonstationary fluctuation analysis of the EPSCs at a bouton indicated that about 120 ACh receptor channels were available beneath boutons for interaction with a quantum of ACh. The characteristics of these EPSCs were compared with the results of Monte Carlo simulations of the quantal release of 9000 acetylcholine (ACh) molecules onto receptor patches of density 1400 microns-2 and 0.41 micron diameter, using a kinetic scheme of interaction between ACh and the receptors similar to that observed at the neuromuscular junction. The simulated EPSC generated in this way had temporal characteristics similar to those of the experimental EPSC when either the diffusion of the ACh is slowed or allowance is made for a finite period of transmitter release from the bouton. The amplitude of the simulated EPSC then exhibited stochastic fluctuations similar to those of the experimental EPSC.
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