ArticleJournal of bacteriology1997
Identification, characterization, and chromosomal organization of cell division cycle genes in Caulobacter crescentus.
Article in Journal of bacteriology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Synchronized Swarmers and Sticky Stalks: Caulobacter crescentus as a Model for Bacterial Cell Biology.Journal of bacteriology · 2023Review
- A CRISPR interference platform for selective downregulation of gene expression inApplied and environmental microbiology · 2021Article
- FtsA Regulates Z-Ring Morphology and Cell Wall Metabolism in an FtsZ C-Terminal Linker-Dependent Manner in Caulobacter crescentus.Journal of bacteriology · 2020Article
- Untargeted metabolomics links glutathione to bacterial cell cycle progression.Nature metabolism · 2020Article
- A novel membrane anchor for FtsZ is linked to cell wall hydrolysis in Caulobacter crescentus.Molecular microbiology · 2016Article
- The coding and noncoding architecture of the Caulobacter crescentus genome.PLoS genetics · 2014Article
- Diverse functions for six glycosyltransferases in Caulobacter crescentus cell wall assembly.Journal of bacteriology · 2013Article
- Assembly of the Caulobacter cell division machine.Molecular microbiology · 2011Article
- A protein critical for cell constriction in the Gram-negative bacterium Caulobacter crescentus localizes at the division site through its peptidoglycan-binding LysM domains.Molecular microbiology · 2010Article
- Getting in the loop: regulation of development in Caulobacter crescentus.Microbiology and molecular biology reviews : MMBR · 2010Review
- Complex regulatory pathways coordinate cell-cycle progression and development in Caulobacter crescentus.Advances in microbial physiology · 2009Review
- Localization of PBP3 in Caulobacter crescentus is highly dynamic and largely relies on its functional transpeptidase domain.Molecular microbiology · 2008Article
- A quantitative study of the division cycle of Caulobacter crescentus stalked cells.PLoS computational biology · 2008Article
- The bifunctional FtsK protein mediates chromosome partitioning and cell division in Caulobacter.Journal of bacteriology · 2006Article
- The topoisomerase IV ParC subunit colocalizes with the Caulobacter replisome and is required for polar localization of replication origins.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Protein sequences and cellular factors required for polar localization of a histidine kinase in Caulobacter crescentus.Journal of bacteriology · 2002Article
- Cell cycle expression and transcriptional regulation of DNA topoisomerase IV genes in caulobacter.Journal of bacteriology · 1999Article
- Cell cycle-dependent transcriptional and proteolytic regulation of FtsZ in Caulobacter.Genes & development · 1998Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a detailed characterization of cell division cycle (cdc) genes in the differentiating gram-negative bacterium Caulobacter crescentus. A large set of temperature-sensitive cdc mutations was isolated after treatment with the chemical mutagen N-methyl-N'-nitro-N-nitrosoguanidine. Analysis of independently isolated mutants at the nonpermissive temperature identified a variety of well-defined terminal phenotypes, including long filamentous cells blocked at various stages of the cell division cycle and two unusual classes of mutants with defects in both cell growth and division. The latter strains are uniformly arrested as either short bagel-shaped coils or large predivisional cells. The polar morphology of these cdc mutants supports the hypothesis that normal cell cycle progression is directly responsible for developmental regulation in C. crescentus. Genetic and physical mapping of the conditional cdc mutations and the previously characterized dna and div mutations identified at least 21 genes that are required for normal cell cycle progression. Although most of these genes are widely scattered, the genetically linked divA, divB, and divE genes were shown by genetic complementation and physical mapping to be organized in one gene cluster at 3200 units on the chromosome. DNA sequence analysis and marker rescue experiments demonstrated that divE is the C. crescentus ftsA homolog and that the ftsZ gene maps immediately adjacent to ftsA. On the basis of these results, we suggest that the C. crescentus divA-divB-divE(ftsA)-ftsZ gene cluster corresponds to the 2-min fts gene cluster of Escherichia coli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.