Evidence map›Paper›PMID 9071580›Full record

ArticleGenetics1997

Interaction between Ustilago maydis REC2 and RAD51 genes in DNA repair and mitotic recombination.

D O Ferguson, M C Rice, M H Rendi, H Kotani, E B Kmiec, W K Holloman

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

  1. Global Gene Expression of Post-Senescent Telomerase-NegativeJournal of fungi (Basel, Switzerland) · 2023
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The homologous recombination system of Ustilago maydis.Fungal genetics and biology : FG & B · 2008
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis.Proceedings of the National Academy of Sciences of the United States of America · 1997
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

D O FergusonHearst Microbiology Research Center, Department of Microbiology, Cornell University Medical College, New York, New York 10021, USA.
M C Rice
M H Rendi
H Kotani
E B Kmiec
W K Holloman
Cornell University · USThomas Jefferson University · USHearst (United States) · USSidney Kimmel Cancer Center · US

Funding

GENETIC RECOMBINATION MECHANISMSR01GM053732 · NIGMS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI HOLLOMAN, WILLIAM K. · 1996 to 1998
–
NIGMS NIH HHS GM-53732
6 · The paper itself

Abstract

A gene encoding a Ustilago maydis Rad51 orthologue has been isolated, rad51-1, a mutant constructed by disrupting the gene, was as sensitive to killing by ultraviolet light and gamma radiation as the rec2-1 mutant and slightly more sensitive to killing by methyl methanesulfonate. There was no suppression of killing by ultraviolet light when a rec2-1 strain was transformed with a multicopy plasmid containing RAD51, nor was there suppression when rad51-1 was transformed with a multicopy plasmid containing REC2. Recombination proficiency as measured by a gap repair assay was diminished in both rec2-1 and rad51-1 strains. In rec2-1 the frequency of recombination was decreased, but the spectrum of events was similar to that observed in wild type, while in rad51-1 the frequency as well as the spectrum of recombination events were different. Studies with the rec2-1 rad51-1 double mutant indicated that there was epistasis in the action of REC2 and RAD51 in certain repair and recombination functions, but some measure of independent action in other functions.

Indexed as

DNA RepairAmino Acid SequenceBase SequenceChromosomes, FungalDNA-Binding ProteinsDNA, FungalFungal ProteinsGamma RaysGene Expression RegulationGenes, FungalMitosisMolecular Sequence DataPlasmidsRad51 RecombinaseRecombination, GeneticUltraviolet RaysDNA-Binding ProteinsDNA, FungalFungal ProteinsRad51 RecombinaseREC2 protein, Ustilago maydis

Identifiers

PMID9071580
PMCPMC1207791
OpenAlexW1887353620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.