ArticleMammalian genome : official journal of the International Mammalian Genome Society1997
Interval-specific congenic strains (ISCS): an experimental design for mapping a QTL into a 1-centimorgan interval.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
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- A Strategy for Identifying Quantitative Trait Genes Using Gene Expression Analysis and Causal Analysis.Genes · 2017Review
- How mice are indispensable for understanding obesity and diabetes genetics.Current opinion in endocrinology, diabetes, and obesity · 2017Review
- Targeted Recombinant Progeny: a design for ultra-high resolution mapping of Quantitative Trait Loci in crosses between inbred or pure lines.BMC genetics · 2015Article
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- Microarray-assisted fine mapping of quantitative trait loci on chromosome 15 for susceptibility to seizure-induced cell death in mice.The European journal of neuroscience · 2013Article
- Fine mapping of the Bmgr5 quantitative trait locus for allogeneic bone marrow engraftment in mice.Immunogenetics · 2013Article
- Disease-promoting and -protective genomic loci on mouse chromosomes 3 and 19 control the incidence and severity of autoimmune arthritis.Genes and immunity · 2012Article
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- Intersubspecific subcongenic mouse strain analysis reveals closely linked QTLs with opposite effects on body weight.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Congenic strains provide evidence that a mapped locus on chromosome 15 influences excitotoxic cell death.Genes, brain, and behavior · 2011Article
- High resolution mapping of trypanosomosis resistance loci Tir2 and Tir3 using F12 advanced intercross lines with major locus Tir1 fixed for the susceptible allele.BMC genomics · 2010Article
- Allelic variation in the Tyk2 and EGF genes as potential genetic determinants of CNS repair.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Four additional mouse crosses improve the lipid QTL landscape and identify Lipg as a QTL gene.Journal of lipid research · 2009Article
- Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- A major QTL for acute ethanol sensitivity in the alcohol tolerant and non-tolerant selected rat lines.Genes, brain, and behavior · 2009Article
- The alpha 3 subunit gene of the nicotinic acetylcholine receptor is a candidate gene for ethanol stimulation.Genes, brain, and behavior · 2009Article
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Abstract
A general experimental design that allows mapping of a quantitative trait locus (QTL) into a 1-cM interval is presented. The design consists of a series of strains, termed "interval-specific congenic strains (ISCS)". Each ISCS is recombinant at a specific 1-cM sub-interval out of an ordered set of sub-intervals, which together comprise a wider interval, to which a QTL was previously mapped. It is shown that a specific and previously detected QTL of moderate or even small effect can be accurately mapped into a 1-cM interval in a program involving a total of no more than 1000 individuals. Consequently, ISCS can serve as the ultimate genetic mapping procedure before the application of physical mapping tools for positional cloning of a QTL.
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