ArticleJournal of bacteriology1997
Identification and characterization of the ccdA gene, required for cytochrome c synthesis in Bacillus subtilis.
Article in Journal of bacteriology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 91 citations in OpenAlex.
- Analysis of putative heme ligands in the System I bacterial cytochromeMicrobiology spectrum · 2026Article
- From genes to function: regulation, maturation, and evolution of cytochromeApplied and environmental microbiology · 2025Review
- Helicobacter pylori and Campylobacter jejuni bacterial holocytochrome c synthase structure-function analysis reveals conservation of heme binding.Communications biology · 2024Article
- Article
- Cryo-EM of CcsBA reveals the basis for cytochrome c biogenesis and heme transport.Nature chemical biology · 2022Article
- Identification of Redox Partners of the Thiol-Disulfide Oxidoreductase SdbA in Streptococcus gordonii.Journal of bacteriology · 2019Article
- Article
- The two CcdA proteins of Bacillus anthracis differentially affect virulence gene expression and sporulation.Journal of bacteriology · 2013Article
- The CcmC:heme:CcmE complex in heme trafficking and cytochrome c biosynthesis.Journal of molecular biology · 2010Article
- Applications of thiol-disulfide oxidoreductases for optimized in vivo production of functionally active proteins in Bacillus.Applied microbiology and biotechnology · 2009Review
- Cytochrome c biogenesis: mechanisms for covalent modifications and trafficking of heme and for heme-iron redox control.Microbiology and molecular biology reviews : MMBR · 2009Review
- CcsBA is a cytochrome c synthetase that also functions in heme transport.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Structure and functional properties of Bacillus subtilis endospore biogenesis factor StoA.The Journal of biological chemistry · 2009Article
- The active-site cysteinyls and hydrophobic cavity residues of ResA are important for cytochrome c maturation in Bacillus subtilis.Journal of bacteriology · 2008Article
- Extracytoplasmic processes impaired by inactivation of trxA (thioredoxin gene) in Bacillus subtilis.Journal of bacteriology · 2008Article
- Heme concentration dependence and metalloporphyrin inhibition of the system I and II cytochrome c assembly pathways.Journal of bacteriology · 2007Article
- Mechanism of substrate specificity in Bacillus subtilis ResA, a thioredoxin-like protein involved in cytochrome c maturation.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Heme A synthase enzyme functions dissected by mutagenesis of Bacillus subtilis CtaA.Journal of bacteriology · 2005Article
- Cytochrome c maturation and the physiological role of c-type cytochromes in Vibrio cholerae.Journal of bacteriology · 2005Article
- Mutations in cytochrome assembly and periplasmic redox pathways in Bordetella pertussis.Journal of bacteriology · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gram-positive, endospore-forming bacterium Bacillus subtilis contains several membrane-bound c-type cytochromes. We have isolated a mutant pleiotropically deficient in cytochromes c. The responsible mutation resides in a gene which we have named ccdA (cytochrome c defective). This gene is located at 173 degrees on the B. subtilis chromosome. The ccdA gene was found to be specifically required for synthesis of cytochromes of the c type. CcdA is a predicted 26-kDa integral membrane protein with no clear similarity to any known cytochrome c biogenesis protein but seems to be related to a part of Escherichia coli DipZ/DsbD. The ccdA gene is cotranscribed with two other genes. These genes encode a putative 13.5-kDa single-domain response regulator, similar to B. subtilis CheY and Spo0F, and a predicted 18-kDa hydrophobic protein with no similarity to any protein in databases, respectively. Inactivation of the three genes showed that only ccdA is required for cytochrome c synthesis. The results also demonstrated that cytochromes of the c type are not needed for growth of B. subtilis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.