Trial reportArchives of disease in childhood1997
Double blind placebo controlled trial of nebulised budesonide for croup.
Trial report in Archives of disease in childhood, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Glucocorticoids for croup in children.The Cochrane database of systematic reviews · 2023Pooled it
- Glucocorticoids for croup in children.The Cochrane database of systematic reviews · 2018Pooled it
- Nebulized epinephrine for croup in children.The Cochrane database of systematic reviews · 2013Pooled it
- Nebulised steroid in the treatment of croup: a systematic review of randomised controlled trials.The British journal of general practice : the journal of the Royal College of General Practitioners · 2000Pooled it
- Review
- Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases.Italian journal of pediatrics · 2021Article
- Acute respiratory distress in patient with laryngeal schwannoma.Case reports in medicine · 2012Article
- A cluster randomized controlled trial comparing three methods of disseminating practice guidelines for children with croup [ISRCTN73394937].Implementation science : IS · 2006Article
- Antiasthmatic drug delivery in children.Paediatric drugs · 2002Review
- Management of croup.Paediatric drugs · 2002Review
- Interobserver variability of croup scoring in clinical practice.Paediatrics & child health · 2001Article
- Review
- Do steroids prevent reintubation in children with laryngotracheobronchitis?Critical care (London, England) · 2000Article
- Role of steroids in treatment of croup.Indian journal of pediatrics · 2000Article
- Effectiveness of glucocorticoids in treating croup. Authors acknowledge Cochrane Collaboration.BMJ (Clinical research ed.) · 1999Article
- Management of childhood croup.Thorax · 1997Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine whether nebulised budesonide improves the symptoms or shortens the duration of stay of children admitted to hospital with a clinical diagnosis of croup.
methodsA prospective, randomised, double blind placebo controlled trial. Patients received either nebulised budesonide or placebo every 12 hours. The main outcome measures were duration of inpatient stay and croup scores at 30 minutes, one, two, four, 12, and 24 hours.
results87 patients (89 admissions) aged 7-116 months entered the trial. Nebulised budesonide was associated with a significant improvement in symptoms at 12 hours (95% confidence interval (CI) 1 to 3) and 24 hours (95% CI 0 to 3). Patients with an initial croup score above 3 demonstrated a significant improvement in symptoms at two hours (95% CI 1 to 3). Nebulised budesonide was also associated with a 33% reduction in the length of stay (95% CI 2% to 63%) when the confounding variables of age, initial croup score, and coryzal symptoms were taken into consideration.
conclusionsNebulised budesonide is an effective treatment for children admitted to hospital with a clinical diagnosis of croup.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.