ReviewJournal of bioenergetics and biomembranes1997
Homologous and heterologous interactions between hexokinase and mitochondrial porin: evolutionary implications.
Review in Journal of bioenergetics and biomembranes, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- Apoptotic proteins with non-apoptotic activity: expression and function in cancer.Apoptosis : an international journal on programmed cell death · 2023Review
- A role for F-actin in hexokinase-mediated glucose signaling.Plant physiology · 2007Article
- Prediction of protein orientation upon immobilization on biological and nonbiological surfaces.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.Oncogene · 2006Review
- The mitochondrial outer membrane is not a major diffusion barrier for ADP in mouse heart skinned fibre bundles.Pflugers Archiv : European journal of physiology · 2004Article
- Plant mitochondria actively import DNA via the permeability transition pore complex.The EMBO journal · 2003Article
- Hexokinase 'binding sites' of normal and tumoral human brain mitochondria.Molecular and cellular biochemistry · 2000Article
- Binding of rat brain hexokinase to recombinant yeast mitochondria: identification of necessary molecular determinants.Journal of bioenergetics and biomembranes · 1999Article
- Binding of rat brain hexokinase to recombinant yeast mitochondria: effect of environmental factors and the source of porin.Journal of bioenergetics and biomembranes · 1998Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Binding of the Type I isozyme of mammalian hexokinase to mitochondria is mediated by the porin present in the outer mitochondrial membrane. Type I hexokinase from rat brain is avidly bound by rat liver mitochondria while, under the same conditions, there is no significant binding to mitochondria from S. cerevisiae. Previously published work demonstrates the lack of significant interaction of yeast hexokinase with mitochondria from either liver or yeast. Thus, structural features required for the interaction of porin and hexokinase must have emerged during evolution of the mammalian forms of these proteins. If these structural features serve no functional role other than facilitating this interaction of hexokinase with mitochondria, it seems likely that they evolved in synchrony since operation of selective pressures on the hexokinase-mitochondrial interaction would require the simultaneous presence of hexokinase and porin capable of at least minimal interaction, and be responsive to changes in either partner that affected this interaction. Recent studies have indicated that a second type of binding site, which may or may not involve porin, is present on mammalian mitochondria. There are also reports of hexokinase binding to mitochondria in plant tissues, but the nature of the binding site remains undefined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.