Evidence map›Paper›PMID 9065506›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997

Regulation of quantal secretion from developing motoneurons by postsynaptic activity-dependent release of NT-3.

J C Liou, W M Fu

Open access · bronzeAbstract read
PubMed Full text at PMC
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Target-dependent regulation of neurotransmitter specification and embryonic neuronal calcium spike activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010
    Article
  3. Late onset muscle plasticity in the whisker pad of enucleated rats.Proceedings of the National Academy of Sciences of the United States of America · 2008
    Article
  4. Article
  5. Article
  6. Article
  7. Optical measurements of presynaptic release in mutant zebrafish lacking postsynaptic receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003
    Article
  8. Review
  9. Muscle spindle-derived neurotrophin 3 regulates synaptic connectivity between muscle sensory and motor neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002
    Article
  10. Retrograde signaling at central synapses.Proceedings of the National Academy of Sciences of the United States of America · 2001
    Review
  11. Article
  12. Article
  13. Long-range signaling within growing neurites mediated by neurotrophin-3.Proceedings of the National Academy of Sciences of the United States of America · 1999
    Article
  14. Article
  15. Article
  16. Article
  17. BDNF and activity-dependent synaptic modulation.Learning & memory (Cold Spring Harbor, N.Y.)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

J C LiouPharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan 100.
W M Fu
National Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurotrophic factors derived from postsynaptic muscle cells may play important roles in the development of presynaptic neuronal functions. In 3-d-old Xenopus nerve-muscle cultures, embryonic spinal neurons that had made natural contact with co-cultured myocytes exhibited spontaneous release of larger packets of acetylcholine (ACh) quanta than those released by the isolated neurons having no contact with any myocyte. Treatment of isolated neurons with neurotrophin-3 (NT-3) for 2 d increased the average sizes of quantal ACh packets at newly formed nerve-muscle synapses, whereas treatment with antibody against NT-3 or with K252a, a specific inhibitor of tyrosine kinase receptors, decreased the quantal size at existing synapses, which suggests that NT-3 supplied by the postsynaptic muscle cell may be responsible for the development and maintenance of the quantal packets. The muscle effect seems to depend on synaptic activities mediated by postsynaptic ACh receptor channels, because chronic treatment of the culture with D-tubocurarine (D-Tc) for 2 d resulted in a marked reduction of the quantal sizes, when assayed after extensive washing of the culture with Ringer's solution. The curare treatment did not affect the postsynaptic ACh receptor sensitivity, because iontophoretically applied ACh induced current responses similar to those of control. Finally, co-treatment of the culture with NT-3 and D-Tc reversed the effect of D-Tc on the quantal size, and this reversal effect was abolished when K252a was also applied concomitantly. Our results suggest that muscle-derived NT-3 participates in the maturation of normal transmitter packets in developing neurons, and the secretion of NT-3 depends on spontaneous synaptic activity.

Indexed as

AcetylcholineAnimalsAntibodiesCarbazolesCell CommunicationCells, CulturedEmbryo, NonmammalianEnzyme InhibitorsEvoked PotentialsIndole AlkaloidsKineticsMembrane PotentialsMotor NeuronsNerve EndingsNerve Growth FactorsNeuromuscular JunctionAcetylcholineAntibodiesCarbazolesEnzyme InhibitorsIndole AlkaloidsNerve Growth FactorsNeurotrophin 3Receptors, Cholinergicstaurosporine aglyconeTubocurarine

Identifiers

PMID9065506
PMCPMC6573501
OpenAlexW2140277219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.