ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Post-transcriptional regulation of synaptic vesicle protein expression and the developmental control of synaptic vesicle formation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 95 citations in OpenAlex.
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- Serotonergic neuron ribosomal proteins regulate the neuroendocrine control of Drosophila development.PLoS genetics · 2022Article
- Gene expression levels of synaptic exocytosis regulator synaptophysin in the brain and the olfactory organ of anadromous salmon.Fish physiology and biochemistry · 2022Article
- CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation.Nature genetics · 2019Article
- Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.The EMBO journal · 2018Article
- Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations.Acta neuropathologica · 2018Article
- Review
- Abnormal expression of synaptophysin, SNAP-25, and synaptotagmin 1 in the hippocampus of kainic acid-exposed rats with behavioral deficits.Cellular and molecular neurobiology · 2014Article
- Synaptic vesicle recycling: steps and principles.The EMBO journal · 2014Review
- The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- Serotonin-mediated synapsin expression is necessary for long-term facilitation of the Aplysia sensorimotor synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Expression and subcellular location of alpha-synuclein during mouse-embryonic development.Cellular and molecular neurobiology · 2010Article
- Sequential onset of presynaptic molecules during olfactory sensory neuron maturation.The Journal of comparative neurology · 2009Article
- Synaptic vesicle protein trafficking at the glutamate synapse.Neuroscience · 2009Review
- Distinct isoforms of the RFX transcription factor DAF-19 regulate ciliogenesis and maintenance of synaptic activity.Molecular biology of the cell · 2008Article
- Elevated synaptophysin I in the prefrontal cortex of human chronic alcoholics.Synapse (New York, N.Y.) · 2008Article
- Comparison of the ontogeny of the vesicular glutamate transporter 3 (VGLUT3) with VGLUT1 and VGLUT2 in the rat retina.Brain research · 2008Article
- Bidirectional regulation of Munc13-3 protein expression by age and dark rearing during the critical period in mouse visual cortex.Neuroscience · 2007Article
- The role of synaptotagmin I C2A calcium-binding domain in synaptic vesicle clustering during synapse formation.The Journal of physiology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regulated expression of synaptic vesicle (SV) proteins during development and the assembly of these proteins into functional SVs are critical aspects of nervous system maturation. We have examined the expression patterns of four SV proteins in embryonic hippocampal neurons developing in culture and have found that increases in the levels of these proteins result primarily from post-transcriptional regulation. Synaptotagmin I, vamp 2, and synapsin I proteins are synthesized at nearly constant rates as the neurons develop. However, these proteins are relatively unstable at early times in culture and undergo a progressive increase in half-life with time, possibly as a result of an increase in the efficiency with which they are incorporated into SVs. In contrast, synaptophysin is synthesized at a very low rate at early times in culture, and its rate of synthesis increases dramatically with time. The increase in synaptophysin synthesis is not simply the result of an increase in mRNA level, but is largely attributable to an increase in the rate of translational initiation. Despite the nearly constant rates of synthesis of synaptotagmin I, vamp 2, and synapsin I, we show that the number of SVs in these developing neurons increases, and that SV proteins are more efficiently targeted to SVs at later times in culture. Our results suggest that SV production during development is not limited by the rates of transcription of genes encoding the component proteins, thus allowing control of this process by cytoplasmic mechanisms, without signaling to the nucleus.
Indexed as
Identifiers
9065497PMC6573495W2147611640What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.