ArticleAnnals of surgery1997
Calcium regulation and bone mass loss after total gastrectomy in pigs.
Article in Annals of surgery, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Risk factors of osteoporosis in post-gastrectomy gastric cancer patients: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- The effect of supplementation of a glutamine precursor on the growth plate, articular cartilage and cancellous bone in fundectomy-induced osteopenic bone.The Journal of veterinary medical science · 2016Trial
- Early phase metabolic bone disorders after gastrectomy: influence of active vitamin D treatment.Digestive diseases and sciences · 2002Trial
- Synergistic Effects of 25-Hydroxyvitamin DAnimals : an open access journal from MDPI · 2026Article
- Effects of 25-hydroxyvitamin DAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Osteoporosis and Osteoporotic Fractures in Gastrointestinal Disease.Journal of bone metabolism · 2018Review
- Risk of osteoporosis after gastrectomy in long-term gastric cancer survivors.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2018Article
- Bone metabolism after bariatric surgery.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Review
- The role of the gastrointestinal tract in calcium homeostasis and bone remodeling.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Review
- Influence of gastrectomy on cortical and cancellous bones in rats.Gastroenterology research and practice · 2013Article
- Prevalence, pathophysiology, screening and management of osteoporosis in gastric cancer patients.Journal of gastric cancer · 2011Article
- Mineral metabolism and bone disease after bariatric surgery and ways to optimize bone health.Obesity surgery · 2007Review
- Postgastrectomy osteopenia in minipigs.Annals of surgery · 1999Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTotal gastrectomy often results in postgastrectomy bone disease with decreased bone mass and increased fracture risk. To further elucidate the mechanisms of postgastrectomy bone disease, the authors investigated calcium metabolism and bone mineral density after total gastrectomy in pigs. SUMMARY BACKGROUND DATA: Postgastrectomy bone disease can present as osteomalacia, osteoporosis in excess of normal aging, or a combination of both. The underlying mechanisms are insufficiently understood and need further investigation.
methodsGrowing minipigs were gastrectomized and compared with fed-matched, sham-operated control p gs for 1 year. Calcium absorption, serum calcium, parathyroid hormone, 25-(OH)-vitamin D, 1,25-(OH)2-vitamin D, alkaline phosphatase, and computed tomography bone mineral density were measured in three monthly intervals.
resultsTotal gastrectomy resulted in impaired calcium absorption, reduced serum calcium and 25-(OH)-vitamin D, increased parathyroid hormone and 1,25-(OH)2-vitamin, and reduced bone mineral density compared with fed-matched, sham-operated control pigs.
conclusionsThe authors data indicate that a reduced serum calcium activates counter-regulatory mechanisms, resulting in calcium mobilization from the bone. Possibly, calcium and vitamin D supplementation after total gastrectomy might prevent postgastrectomy bone mass loss.
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