ArticleThe Journal of experimental medicine1996
Identification of a costimulatory molecule rapidly induced by CD40L as CD44H.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 106 citations in OpenAlex.
- The Invisible Lens: Why Theoretical Models Are Essential for Interpreting Immune Phenomena.Scandinavian journal of immunology · 2025Review
- KDM1A epigenetically enhances RAD51 expression to suppress the STING-associated anti-tumor immunity in esophageal squamous cell carcinoma.Cell death & disease · 2024Article
- Increased expression of surface CD44 in hypoxia-DCs skews helper T cells toward a Th2 polarization.Scientific reports · 2015Article
- Differences in CD44 Surface Expression Levels and Function Discriminates IL-17 and IFN-γ Producing Helper T Cells.PloS one · 2015Article
- Why can't the immune system control HIV-1? Defining HIV-1-specific CD4+ T cell immunity in order to develop strategies to enhance viral immunity.Immunologic research · 2006Review
- Article
- Nitric oxide limits the expansion of antigen-specific T cells in mice infected with the microfilariae of Brugia pahangi.Infection and immunity · 2002Article
- The transmembrane form of TNF-alpha drives autoantibody production in the absence of CD154: studies using MRL/Mp-Fas(lpr) mice.Clinical and experimental immunology · 2002Article
- The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation.The Journal of clinical investigation · 2001Article
- Inhibition of the function of the FcgammaRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen.Immunology · 2001Article
- Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7).The Journal of experimental medicine · 2000Article
- Expression of CD44 on bile ducts in primary sclerosing cholangitis and primary biliary cirrhosis.Journal of clinical pathology · 1999Article
- Immunomodulation by interference with co-stimulatory molecules: therapeutic perspectives in asthma.Thorax · 1999Review
- A two-step, two-signal model for the primary activation of precursor helper T cells.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Immunological self/nonself discrimination: integration of self vs nonself during cognate T cell interactions with antigen-presenting cells.Immunologic research · 1999Review
- CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge.Journal of immunology (Baltimore, Md. : 1950) · 1998Article
- CD40 ligand-mediated interactions are involved in the generation of memory CD8(+) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection.Journal of virology · 1998Article
- CD28-independent induction of T helper cells and immunoglobulin class switches requires costimulation by the heat-stable antigen.The Journal of experimental medicine · 1998Article
- A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction.The Journal of experimental medicine · 1997Article
- CTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion.The Journal of experimental medicine · 1997Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
The interaction between CD40 ligand and CD40 is critical for activation of T and B cells in vivo. We have recently demonstrated that this interaction rapidly induces a novel costimulatory activity distinct from B7 and independent of CD28. To study the molecular basis of the costimulatory activity, we have produced a novel monoclonal antibody, TM-1, that binds an 85-kilodalton costimulatory molecule rapidly induced by CD40L. Expression cloning reveals that TM-1 binds CD44H. CD44H expressed on Chinese hamster ovary cells has potent costimulatory activity for clonal expansion of T cells isolated from both wild-type mice and these with a targeted mutation of CD28. Thus, CD44H costimulates T cell proliferation by a CD28-independent mechanism. These results revealed that CD44H is a costimulatory molecule rapidly induced by CD40L.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.