ArticleThe Journal of experimental medicine1996
Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed.
- Thymic Dendritic Cells Revisited.Immunological reviews · 2025Review
- Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance.Immunological reviews · 2025Review
- DCs at the center of help: Origins and evolution of the three-cell-type hypothesis.The Journal of experimental medicine · 2022Article
- The thymic microenvironment gradually modulates the phenotype of thymus-homing peripheral conventional dendritic cells.Immunity, inflammation and disease · 2022Article
- The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors.Cells · 2021Review
- Kinetics of immune cell responses in the multiple low-dose streptozotocin mouse model of type 1 diabetes.FASEB bioAdvances · 2019Article
- An enriched network motif family regulates multistep cell fate transitions with restricted reversibility.PLoS computational biology · 2019Article
- Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development.Frontiers in immunology · 2019Review
- Development of an adenovirus vector vaccine platform for targeting dendritic cells.Cancer gene therapy · 2018Article
- The development and function of dendritic cell populations and their regulation by miRNAs.Protein & cell · 2017Review
- Bovine WC1Frontiers in immunology · 2017Article
- Dendritic cell development-History, advances, and open questions.Seminars in immunology · 2015Review
- The Role of Dendritic Cells in Central Tolerance.Immune network · 2015Review
- Fli-1 regulates the DN2 to DN3 thymocyte transition and promotes γδ T-cell commitment by enhancing TCR signal strength.European journal of immunology · 2014Article
- Leishmania amazonensis infection impairs dendritic cell migration from the inflammatory site to the draining lymph node.BMC infectious diseases · 2014Article
- Transcriptional control of early T and B cell developmental choices.Annual review of immunology · 2014Review
- Two waves of distinct hematopoietic progenitor cells colonize the fetal thymus.Nature immunology · 2014Article
- Article
- Dendritic cell development: a choose-your-own-adventure story.Advances in hematology · 2013Article
- The bloodline of CD8α(+) dendritic cells.Molecules and cells · 2012Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Successive T-precursors isolated from adult mouse thymus were examined for their developmental potential, by transfer to irradiated Ly 5-disparate recipients. The earliest, "low CD4" precursors formed T, B, and dendritic cells (DC), but not myeloid cells, in accordance with earlier studies. Surprisingly, the next downstream CD4-8-3 44+25+ precursor population still formed DC as well as T cells although it no longer formed B or myeloid cells. Further down-stream, the CD4-8 3-44-25+ population formed only T cells. The thymic and splenic DC progeny of the early thymic precursors all expressed high levels of CD8 alpha, in contrast with normal splenic DC and the splenic DC progeny of bone marrow stem cells, which consisted of both CD8 and CD8+ DC. A common precursor of T cells and of a subclass of DC is proposed, with CD8 alpha as a marker of the lymphoid-related DC lineage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.