ArticleThe Journal of experimental medicine1996
T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 101 citations in OpenAlex.
- Effect of Age on Xenobiotic-Induced Autoimmunity.bioRxiv : the preprint server for biology · 2025Article
- Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5Immunity · 2022Article
- A Biological and Immunological Characterization ofInternational journal of molecular sciences · 2020Article
- Germinal Center Cells Turning to the Dark Side: Neoplasms of B Cells, Follicular Helper T Cells, and Follicular Dendritic Cells.Frontiers in oncology · 2020Review
- T-bet in Tfh cells: Now you see me, now you don't.The Journal of experimental medicine · 2018Article
- Molecular Control of Follicular Helper T cell Development and Differentiation.Frontiers in immunology · 2018Review
- Clonal and cellular dynamics in germinal centers.Current opinion in immunology · 2014Review
- T follicular helper cell dynamics in germinal centers.Science (New York, N.Y.) · 2013Article
- AID expression during B-cell development: searching for answers.Immunologic research · 2011Article
- T-cell receptor revision: friend or foe?Immunology · 2010Review
- Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Follicular helper T cells as cognate regulators of B cell immunity.Current opinion in immunology · 2009Review
- Follicular helper T cells: lineage and location.Immunity · 2009Review
- CD8 T cells are required for the formation of ectopic germinal centers in rheumatoid synovitis.The Journal of experimental medicine · 2002Article
- Highly restricted spread of HIV-1 and multiply infected cells within splenic germinal centers.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Fortifying B cells with CD154: an engaging tale of many hues.Immunology · 2000Review
- Role of OX40 signals in coordinating CD4 T cell selection, migration, and cytokine differentiation in T helper (Th)1 and Th2 cells.The Journal of experimental medicine · 2000Review
- Studies of the humoral immune response.Immunologic research · 2000Review
- Antigen-specific immunity. Th cell-dependent B cell responses.Immunologic research · 2000Review
- Mice transgenic for a soluble form of murine cytotoxic T lymphocyte antigen 4 are refractory to murine acquired immune deficiency sydrome development.Immunology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
After immunization, activated splenic T cells proliferate in periarteriolar lymphoid sheaths (PALS) and subsequently migrate to the lymphoid follicle where they enter nascent germinal centers. Analysis of TCR V(D)J gene rearrangements indicates extensive emigration, frequently involving more than a single white pulp region. These migrants constitute a unique set of T helper cells that express antigen-specific alpha beta TCR, CD3, and CD4, but little or no Thy-1, a differentiation antigen present on the great majority of peripheral murine T lymphocytes. The origin of CD4+ Thy-1 follicular T cells appears to be the Thy+ population in the PALS, as both sets commonly share identical V(D)J rearrangements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.