ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology1997
Clearances of Candida albicans-derived alpha- and beta-linked mannose residues in sera from patients with candidiasis.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Antibodies as Models and Tools to DecipherJournal of fungi (Basel, Switzerland) · 2023Review
- Dissection of the anti-Candida albicans mannan immune response using synthetic oligomannosides reveals unique properties of β-1,2 mannotriose protective epitopes.Scientific reports · 2021Article
- Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part I. Epidemiology and diagnosis.Intensive care medicine · 2009Review
- Comparison of the hydrophobic properties of Candida albicans and Candida dubliniensis.Infection and immunity · 2001Article
- New enzyme immunoassays for sensitive detection of circulating Candida albicans mannan and antimannan antibodies: useful combined test for diagnosis of systemic candidiasis.Journal of clinical microbiology · 1999Article
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Authors and funding
6 authors.
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Abstract
Two monoclonal antibodies (MAbs) reacting with different Candida albicans mannan oligomannosidic epitopes were used to detect antigens in human sera. The first MAb reacted with alpha-linked mannose residues shared by mannoproteins, and the second displayed reactivity against beta-1,2-linked oligomannosides shared by phospholipomannan. Two latex agglutination tests performed after dissociation of serum immune complexes were 100% specific. In a retrospective analysis of 39 sera from 20 patients with candidiasis, each test detected seven patients; in combination, they detected ten. More than 60% of positive samples were positive with only one test. These results demonstrate that the clearance of Candida albicans antigens from the blood differs according to the type of oligomannoside and glycoconjugate. Antigen detection kits with MAbs to different Candida albicans mannan epitopes could provide a logical rationale to compensate for the transitory character of mannanemia detection during candidal infections.
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Registered trials
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