ArticleClinical & experimental metastasis1997
A novel spontaneous metastasis model of human osteosarcoma developed using orthotopic transplantation of intact tumor tissue into tibia of nude mice.
Article in Clinical & experimental metastasis, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The Osteosarcoma Tumor Microenvironment: From Cellular Interactions to Advanced Preclinical Models.Cancers · 2026Review
- The generation and use of animal models of osteosarcoma in cancer research.Genes & diseases · 2024Review
- Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Article
- Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Research models and mesenchymal/epithelial plasticity of osteosarcoma.Cell & bioscience · 2021Review
- Review
- A Novel Orthotopic Implantation Technique for Osteosarcoma Produces Spontaneous Metastases and Illustrates Dose-Dependent Efficacy of B7-H3-CAR T Cells.Frontiers in immunology · 2021Article
- An association between successful engraftment of osteosarcoma patient-derived xenografts and clinicopathological findings.Histology and histopathology · 2020Article
- Combinatorial screening using orthotopic patient derived xenograft-expanded early phase cultures of osteosarcoma identify novel therapeutic drug combinations.Cancer letters · 2019Article
- Patient-derived xenograft models in musculoskeletal malignancies.Journal of translational medicine · 2018Review
- Polyphyllin I suppresses human osteosarcoma growth by inactivation of Wnt/β-catenin pathway in vitro and in vivo.Scientific reports · 2017Article
- Cisplatin-resistant osteosarcoma cells possess cancer stem cell properties in a mouse model.Oncology letters · 2016Article
- Establishment of a patient-derived orthotopic osteosarcoma mouse model.Journal of translational medicine · 2015Article
- Osteosarcoma: mouse models, cell of origin and cancer stem cell.Postdoc journal : a journal of postdoctoral research and postdoctoral affairs · 2014Article
- Animal models in osteosarcoma.Frontiers in oncology · 2014Review
- Osteosarcoma models: from cell lines to zebrafish.Sarcoma · 2012Article
- Effect of zoledronic acid and amputation on bone invasion and lung metastasis of canine osteosarcoma in nude mice.Clinical & experimental metastasis · 2011Article
- An orthotopic, postsurgical model of luciferase transfected murine osteosarcoma with spontaneous metastasis.Clinical & experimental metastasis · 2010Article
- Establishment and characterization of human osteosarcoma cell lines with different pulmonary metastatic potentials.Cytotechnology · 2009Article
- Metastatic osteosarcoma gene expression differs in vitro and in vivo.Clinical orthopaedics and related research · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evaluation of potential new treatment strategies requires adequate experimental tumor models which resemble the clinical situation as closely as possible. The purpose of the present study was to establish a new human osteosarcoma spontaneous metastasis model using orthotopic transplantation of histologically intact tumor tissue into the tibia of nude mice. Intact tumor pieces, obtained from the 32nd serial passage of subcutaneously growing human osteosarcoma xenografts, were implanted into the proximal tibia in 31 nude mice. Animals were sacrificed and autopsied 2, 4, 6, and 8 weeks after transplantation and examined macroscopically and microscopically for local tumor growth and metastases. All mice developed local intratibial bone tumors that were radiographically and histologically similar to primary human osteosarcoma. Lung metastases were observed in all mice, local and distant lymph node metastases in 15 (48%), and liver metastases in 6 (19%) mice. The microscopic appearance of the metastases was similar to that observed in the donor patient's tumor, corresponding subcutaneous xenografts and orthotopically transplanted intratibial tumors. This spontaneous metastasis model of human osteosarcoma in nude mice may resemble a clinical situation and could thus be useful for studies on local tumor growth, metastasis formation and therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.