Trial reportThe Journal of clinical investigation1997
Comparison of the direct and indirect effects of epinephrine on hepatic glucose production.
Trial report in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 81 citations in OpenAlex.
- Article
- The β-Hydroxybutyrate-GPR109A Receptor Regulates Fasting-induced Plasticity in the Mouse Adrenal Medulla.Endocrinology · 2022Article
- Adipocyte lipolysis drives acute stress-induced insulin resistance.Scientific reports · 2020Article
- Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity.Diabetologia · 2020Article
- The kinetics of glucagon action on the liver during insulin-induced hypoglycemia.American journal of physiology. Endocrinology and metabolism · 2020Article
- Recurrent hypoglycemia inhibits the counterregulatory response by suppressing adrenal activity.The Journal of clinical investigation · 2018Article
- Glucose autoregulation is the dominant component of the hormone-independent counterregulatory response to hypoglycemia in the conscious dog.American journal of physiology. Endocrinology and metabolism · 2017Article
- AgRP-Expressing Adrenal Chromaffin Cells Are Involved in the Sympathetic Response to Fasting.Endocrinology · 2017Article
- Fasting induces a form of autonomic synaptic plasticity that prevents hypoglycemia.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Hyperglycemia increases the risk of death in extremely preterm baboons.Pediatric research · 2013Article
- Gluconeogenesis and hepatic glycogenolysis during exercise at the lactate threshold.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- A new role for lipocalin prostaglandin d synthase in the regulation of brown adipose tissue substrate utilization.Diabetes · 2012Article
- Physiologic action of glucagon on liver glucose metabolism.Diabetes, obesity & metabolism · 2011Review
- Glucose counterregulatory responses to hypoglycemia.Pediatric endocrinology reviews : PER · 2011Review
- Greater systemic lipolysis in women compared with men during moderate-dose infusion of epinephrine and/or norepinephrine.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
- Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation.The Biochemical journal · 2006Article
- The alternative stimulatory G protein alpha-subunit XLalphas is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice.The Journal of biological chemistry · 2006Article
- Metabolic effects of antihypertensive agents: role of sympathoadrenal and renin-angiotensin systems.Naunyn-Schmiedeberg's archives of pharmacology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
To determine the extent to which the effect of a physiologic increment in epinephrine (EPI) on glucose production (GP) arises indirectly from its action on peripheral tissues (muscle and adipose tissue), epinephrine was infused intraportally (EPI po) or peripherally (EPI pe) into 18-h-fasted conscious dogs maintained on a pancreatic clamp. Arterial EPI levels in EPI po and EPI pe groups rose from 97 +/- 29 to 107 +/- 37 and 42 +/- 12 to 1,064 +/- 144 pg/ml, respectively. Hepatic sinusoidal EPI levels in EPI po and EPI pe were indistinguishable (561 +/- 84 and 568 +/- 75 pg/ml, respectively). During peripheral epinephrine infusion, GP increased from 2.2 +/- 0.1 to 5.1 +/- 0.2 mg/kg x min (10 min). In the presence of the same rise in sinusoidal EPI, but with no rise in arterial EPI (during portal EPI infusion), GP increased from 2.1 +/- 0.1 to 3.8 +/- 0.6 mg/kg x min. Peripheral EPI infusion increased the maximal gluconeogenic rate from 0.7 +/- 0.4 to 1.8 +/- 0.5 mg/ kg x min. Portal EPI infusion did not change the maximal gluconeogenic rate. The estimated initial increase in glycogenolysis was approximately 1.7 and 2.3 mg/kg x min in the EPI pe and EPI po groups, respectively. Gluconeogenesis was responsible for 60% of the overall increase in glucose production stimulated by the increase in plasma epinephrine (EPI pe). Elevation of sinusoidal EPI per se had no direct gluconeogenic effect on the liver, thus its effect on glucose production was solely attributable to an increase in glycogenolysis. Lastly, the gluconeogenic effects of EPI markedly decreased (60-80%) its overall glycogenolytic action on the liver.
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