ArticleThe Journal of clinical investigation1997
Increased cellular expression of matrix proteins that regulate mineralization is associated with calcification of native human and porcine xenograft bioprosthetic heart valves.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 171 citations in OpenAlex.
- Cell Calcification Models and Their Implications for Medicine and Biomaterial Research.Advanced healthcare materials · 2026Review
- Unveiling the Angiogenic Potential and Functional Decline of Valve Interstitial Cells During Calcific Aortic Valve Stenosis Progression.Journal of cellular and molecular medicine · 2025Article
- Calcific Aortic Valve Stenosis with Aging and Current Development in its Pathophysiology.The International journal of angiology : official publication of the International College of Angiology, Inc · 2022Article
- Calcium-Dependent Cytosolic Phospholipase A2α as Key Factor in Calcification of Subdermally Implanted Aortic Valve Leaflets.International journal of molecular sciences · 2022Article
- Bone Health in Patients with Dyslipidemias: An Underestimated Aspect.International journal of molecular sciences · 2022Review
- The Skeleton and Biomineralization Mechanism as Part of the Innate Immune System of Stony Corals.Frontiers in immunology · 2022Review
- Role of Runx2 in Calcific Aortic Valve Disease in Mouse Models.Frontiers in cardiovascular medicine · 2021Article
- Decellularized tissue-engineered heart valves calcification: what do animal and clinical studies tell us?Journal of materials science. Materials in medicine · 2020Review
- Degeneration of Bioprosthetic Heart Valves: Update 2020.Journal of the American Heart Association · 2020Review
- MicroRNA-638 inhibits human aortic valve interstitial cell calcification by targeting Sp7.Journal of cellular and molecular medicine · 2019Article
- Ectopic mineralization in heart valves: new insights fromJournal of thoracic disease · 2019Review
- MicroRNA-449c-5p inhibits osteogenic differentiation of human VICs through Smad4-mediated pathway.Scientific reports · 2017Article
- Serum levels of undercarboxylated osteocalcin are related to cardiovascular risk factors in patients with type 2 diabetes mellitus and healthy subjects.World journal of diabetes · 2017Article
- Pathophysiology of valvular heart disease.Experimental and therapeutic medicine · 2016Article
- Impact of recipient-related factors on structural dysfunction of xenoaortic bioprosthetic heart valves.Patient preference and adherence · 2015Article
- Molecular and cellular aspects of calcific aortic valve disease.Circulation research · 2013Review
- Reduced leaflet stress in the stentless quadrileaflet mitral valve: a finite element model.PloS one · 2013Article
- Liquefaction necrosis of mitral annular calcification (LNMAC): review of pathology, prevalence, imaging and management: proposed diagnostic imaging criteria with detailed multi-modality and MRI image characterization.The international journal of cardiovascular imaging · 2012Review
- Role of osteopontin in early phase of renal crystal formation: immunohistochemical and microstructural comparisons with osteopontin knock-out mice.Urological research · 2012Article
- Matricellular proteins in cardiac adaptation and disease.Physiological reviews · 2012Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Dystrophic mineralization remains the leading cause of stenotic or regurgitant failure in native human and porcine bioprosthetic heart valves. We hypothesized that cellular expression of noncollagenous matrix proteins (osteopontin, osteocalcin, and osteonectin) that regulate skeletal mineralization may orchestrate valvular calcification. Porcine bioprosthetic heart valves and native human heart valves obtained during replacement surgery were analyzed for cells, matrix proteins that regulate mineralization, and vessels. Cell accumulation and calcification were correlated for both valve types (rho = 0.75, P = 0.01, native; rho = 0.42, P = 0.08, bioprosthetic). Osteopontin expression correlated with cell accumulation (rho = 0.58, P = 0.04) and calcification (rho = 0.52, P = 0.06) for bioprosthetic valves. Osteocalcin expression correlated with calcification (rho = 0.77, P = 0.04) and cell accumulation (rho = 0.69, P = 0.07) in native valves. Comparisons of calcified versus noncalcified native and bioprosthetic valves for averaged total matrix protein mRNA signal score revealed increased noncollagenous proteins mRNA levels in calcified valves (P = 0.07, group I vs. group II; P = 0.02, group III vs. group IV). When stratified according to positive versus negative mRNA signal status, both calcified bioprosthetic valves (P = 0.03) and calcified native valves (P = 0.01) were significantly more positive for noncollagenous proteins mRNA than their noncalcified counterparts. Local cell-associated expression of proteins regulating mineralization suggests a highly coordinated mechanism of bioprosthetic and native valve calcification analogous to physiologic bone mineralization. Modulation of cellular infiltration or cellular expression of matrix proteins that regulate mineralization, may offer an effective therapeutic approach to the prevention of valve failure secondary to calcification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.