ArticleThe American journal of pathology1997
Mapping the distribution of neuroepithelial bodies of the rat lung. A whole-mount immunohistochemical approach.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 34 citations in OpenAlex.
- Rare presence and function of neuroendocrine cells in the nasal mucosa.Frontiers in immunology · 2024Article
- Studying the Pulmonary NEB ME: A Multidisciplinary Approach.Advances in anatomy, embryology, and cell biology · 2021Article
- Pulmonary Sensory Receptors.Advances in anatomy, embryology, and cell biology · 2021Article
- Functional Exploration of the Pulmonary NEB ME.Advances in anatomy, embryology, and cell biology · 2021Article
- Pulmonary neuroendocrine cells: physiology, tissue homeostasis and disease.Disease models & mechanisms · 2020Review
- Chemosensory functions for pulmonary neuroendocrine cells.American journal of respiratory cell and molecular biology · 2014Article
- Lung epithelial healing: a modified seed and soil concept.Proceedings of the American Thoracic Society · 2012Article
- A confocal microscopic study of solitary pulmonary neuroendocrine cells in human airway epithelium.Respiratory research · 2005Article
- Alteration of pulmonary neuroendocrine cells during epithelial repair of naphthalene-induced airway injury.The American journal of pathology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We report an immunohistochemical method for mapping the distribution of neuroepithelial bodies (NEBs) in whole-mount preparations of the intrapulmonary airways. The lungs of 8- and 50-day-old male Sprague-Dawley rats were fixed with ethanol-acetic acid by intratracheal instillation. The major axial airway path of the infracardiac lobe was exposed and isolated by microdissection. NEBs were identified by calcitonin gene-related peptide immunoreactivity and their distribution mapped by generation and branch-point number. A distinct pattern was noted with greater prevalence of NEBs in proximal airway generations compared with more distal airways. No significant difference was noted in the distribution pattern or absolute number of NEBs between neonates and adults when compared by airway generation. NEBs were found more frequently on the ridges of the bifurcation than in other regions of the bifurcating airway wall. The ease of identification of total numbers of NEBs and their specific location by airway generation in whole-mount preparations of the bronchial tree completely removes the necessity of examining multiple sections and performing extensive morphometric procedures. Whole-mount airway preparations allow for the analysis and comparison of larger sample sizes per experimental group without labor-intensive approaches. The application of this method should enhance our knowledge of the role of NEBs in lung development and in response to disease.
Indexed as
Identifiers
9060823PMC1857870W67629899What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.