ArticleJournal of virology1997
Identification of a novel antiapoptotic protein, GAM-1, encoded by the CELO adenovirus.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Transcription factor E4F1 as a regulator of cell life and disease progression.Science advances · 2023Review
- Article
- No Genus-Specific Gene Is Essential for the Replication of Fowl Adenovirus 4 in Chicken LMH Cells.Microbiology spectrum · 2022Article
- SUMOylation mediates CtIP's functions in DNA end resection and replication fork protection.Nucleic acids research · 2021Article
- Article
- The role of cullin 5-containing ubiquitin ligases.Cell division · 2016Review
- Expression and in vitro functional analyses of recombinant Gam1 protein.Protein expression and purification · 2015Article
- Contribution of SUMO-interacting motifs and SUMOylation to the antiretroviral properties of TRIM5α.Virology · 2013Article
- Human pathogens and the host cell SUMOylation system.Journal of virology · 2012Review
- Mechanisms, regulation and consequences of protein SUMOylation.The Biochemical journal · 2010Review
- Sequence analysis of the left end of fowl adenovirus genomes.Virus genes · 2006Article
- Viruses and sumoylation: recent highlights.Current opinion in microbiology · 2006Review
- Development of nonhuman adenoviruses as vaccine vectors.Vaccine · 2006Review
- Characterization of a new species of adenovirus in falcons.Journal of clinical microbiology · 2005Article
- Reannotation of the CELO genome characterizes a set of previously unassigned open reading frames and points to novel modes of host interaction in avian adenoviruses.BMC bioinformatics · 2003Article
- Article
- The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1.EMBO reports · 2002Article
- Adenovirus E3-6.7K maintains calcium homeostasis and prevents apoptosis and arachidonic acid release.Journal of virology · 2002Article
- Construction of avian adenovirus CELO recombinants in cosmids.Journal of virology · 2001Article
- Characterization of CELO virus proteins that modulate the pRb/E2F pathway.Journal of virology · 1999Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have developed a simple screening method to identify genes that mimic bcl-2 or adenovirus E1B 19K in enhancing cell survival after transfection and have used this method to identify such a gene in the avian adenovirus CELO. The gene encodes a novel 30-kDa nuclear protein, which we have named GAM-1, that functions comparably to Bcl-2 and adenovirus E1B 19K in blocking apoptosis. However, GAM-1 has no sequence homology to Bcl-2, E1B 19K, or any other known antiapoptotic proteins and thus defines a novel antiapoptotic function.
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