ArticleJournal of virology1997
Specific repression of Tax trans-activation by TAR RNA-binding protein TRBP.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- The multiple functions of TRBP, at the hub of cell responses to viruses, stress, and cancer.Microbiology and molecular biology reviews : MMBR · 2012Review
- Protein components of the microRNA pathway and human diseases.Methods in molecular biology (Clifton, N.J.) · 2009Review
- The HTLV-1 Tax interactome.Retrovirology · 2008Review
- Protein interactions and complexes in human microRNA biogenesis and function.Frontiers in bioscience : a journal and virtual library · 2008Review
- MicroRNAs in gene regulation: when the smallest governs it all.Journal of biomedicine & biotechnology · 2006Article
- Article
- CREB-2, a cellular CRE-dependent transcription repressor, functions in association with Tax as an activator of the human T-cell leukemia virus type 1 promoter.Journal of virology · 1998Article
- Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6.Molecular and cellular biology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human T-cell leukemia virus type 1 (HTLV-1)-encoded Tax protein activates transcription from the long terminal repetition via association with host cellular factors. In this study, we searched for cellular proteins that interact with Tax and modulate its activity by using the yeast two-hybrid system. One of the strongest interactors was found to be identical with TRBP, which was previously shown to bind to the RNA encoded by the Tat response element of human immunodeficiency virus type 1. Interactions are demonstrated with Escherichia coli-expressed proteins in vitro and in mammalian cells, using one- and two-hybrid systems, and with antibodies that coprecipitate Tax and TRBP at physiological TRBP concentrations. Moreover, TRBP, when directed into the cytoplasm, is capable of preventing transport of Tax into the nucleus. A 60-amino-acid polypeptide suffices for binding to Tax. TRBP inhibits activation of transcription by both Tax and GAL4-Tax fusion proteins. Inhibition is specific for Tax and is not seen with the other activators tested. Our data are consistent with the interpretation that TRBP inhibits the interplay of Tax with the transcription machinery or accessory factors.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.