ArticleGenetics1997
Structural and functional differences in the promoter and 5' flanking region of Ldh-B within and between populations of the teleost Fundulus heteroclitus.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 85 citations in OpenAlex.
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- Steep, coincident, and concordant clines in mitochondrial and nuclear-encoded genes in a hybrid zone between subspecies of Atlantic killifish, Fundulus heteroclitus.Ecology and evolution · 2016Article
- The Elizabeth River Story: A Case Study in Evolutionary Toxicology.Journal of toxicology and environmental health. Part B, Critical reviews · 2015Review
- Article
- Comparative characterization of a temperature responsive gene (lactate dehydrogenase-B, ldh-b) in two congeneric tropical fish, Lates calcarifer and Lates niloticus.International journal of biological sciences · 2009Article
- Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2007Article
- Recombinational micro-evolution of functionally different metallothionein promoter alleles from Orchesella cincta.BMC evolutionary biology · 2007Article
- Applications of selective neutrality tests to molecular ecology.Molecular ecology · 2002Review
- Adaptive variation in lactate dehydrogenase-B gene expression: role of a stress-responsive regulatory element.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Major recent and independent changes in levels and patterns of expression have occurred at the b gene, a regulatory locus in maize.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- CORE-SINEs: eukaryotic short interspersed retroposing elements with common sequence motifs.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Transcriptional regulators and the evolution of plant form.The Plant cell · 1998Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated the mechanisms underlying differences in the transcriptional regulation of lactate dehydrogenase-B (Ldh-B) between northern and southern populations of a teleost fish, Fundulus heteroclitus. A 1-kb region immediately 5' of the gene was sequenced from populations throughout the species range. There were two major allele classes in the sample, one containing alleles from Maine and another containing those from Florida. Populations from intermediate localities contained both allele classes. Some individuals from Georgia had sequences intermediate between the two classes, representing either ancestral alleles or recombinants. Tests of neutrality were applied to determine whether observed variation was consistent with neutral expectations. Significant deviations from neutral expectations were detected for the 5' flanking region, but not for other loci. The functional consequences of flanking sequence variation were assessed by transfection of reporter gene constructs into cultured cells and injection into living fish. Consistent with observed variation in Ldh-B transcription rate between populations, significant differences in reporter gene activity were driven by flanking regions from northern and southern populations both in cell culture and in vivo. This functional differentiation, coupled with departures from neutral expectations, suggests that selection may have acted on the regulation of Ldh-B in F. heteroclitus.
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