ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences1997
Level detection in ion channel records via idealization by statistical filtering and likelihood optimization.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Statistical assessment of change point detectors for single molecule kinetic analysis.The Journal of membrane biology · 2013Article
- Test of normality for integrated change point detection and mixture modeling.The Journal of membrane biology · 2013Article
- Modulation of the smooth-muscle L-type Ca2+ channel alpha1 subunit (alpha1C-b) by the beta2a subunit: a peptide which inhibits binding of beta to the I-II linker of alpha1 induces functional uncoupling.The Biochemical journal · 2000Article
- Intracellular Ca2+ inhibits smooth muscle L-type Ca2+ channels by activation of protein phosphatase type 2B and by direct interaction with the channel.The Journal of general physiology · 1997Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A parameter-free method is presented for the level detection in ion channel records via recovery of step wise current changes. No assumptions about ion channel mechanism are made. The primary detection of the transitions is made by statistical filtering the data using the Student's t-test. The event currents are calculated as the average value of the current between two adjacent transitions. An optimal ideal trace is found by maximization of a likelihood function. The distribution of event currents recovered from the raw data is then analysed, again by using the Student's t-test, for their grouping into separate statistical ensembles, defining current levels. The method is subjected to rigorous test using simulated data, and is compared with several other methods. It produces the levels of channel current, their noise amplitudes and distributions of dwell times, the desired information for constructing the channel mechanism.
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