ArticleThe Journal of physiology1997
Oscillation of gap junction electrical coupling in the mouse pancreatic islets of Langerhans.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 58 citations in OpenAlex.
- Functional characteristics of hub and wave-initiator cells in β cell networks.Biophysical journal · 2023Article
- "Take Me To Your Leader": An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets.Diabetes · 2020Review
- Adaptive short-term associative conditioning in the pancreatic β-cell.Physiological reports · 2020Article
- Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Physiological reviews · 2018Review
- Functional connectivity in islets of Langerhans from mouse pancreas tissue slices.PLoS computational biology · 2013Article
- Evidence of diminished glucose stimulation and endoplasmic reticulum function in nonoscillatory pancreatic islets.Endocrinology · 2009Article
- The hyperbolic effect of density and strength of inter beta-cell coupling on islet bursting: a theoretical investigation.Theoretical biology & medical modelling · 2008Article
- Beta cells preferentially exchange cationic molecules via connexin 36 gap junction channels.Diabetologia · 2007Article
- Investigating the role of islet cytoarchitecture in its oscillation using a new beta-cell cluster model.PloS one · 2007Article
- Effects of both glucose and IP3 concentrations on action potentials in pancreatic beta-cells.European biophysics journal : EBJ · 2007Article
- How noise and coupling induce bursting action potentials in pancreatic {beta}-cells.Biophysical journal · 2005Article
- Wave speeds of density dependent Nagumo diffusion equations--inspired by oscillating gap-junction conductance in the islets of Langerhans.Journal of mathematical biology · 2005Article
- Three roads to islet bursting: emergent oscillations in coupled phantom bursters.Biophysical journal · 2004Article
- Excitation wave propagation as a possible mechanism for signal transmission in pancreatic islets of Langerhans.Biophysical journal · 2001Article
- Molecular determinants of membrane potential dependence in vertebrate gap junction channels.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Junctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance.The Journal of clinical investigation · 2000Article
- Activation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells.The Journal of general physiology · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Pancreatic beta-cells oscillate synchronously when grouped in islets. Coupling seems essential to maintain this oscillatory behaviour, as isolated cells are unable to oscillate. This allows the islet to be used as a model system for studying the role of coupling in the generation of oscillatory patterns. 2. Pairs of beta-cells were intracellularly recorded in islets. beta-Cells oscillated synchronously. Propagated voltage deflections were observed as a function of glucose concentration and of the distance between the recording electrodes. Space constants were smaller in the silent than in the active phases, suggesting a higher intercellular connection in the active phases. 3. Coupling coefficients and estimated coupling conductances were larger in the active than in the silent phases. 4. Coupling coefficients and coupling conductances changed dynamically and in phase with the membrane potential oscillations, pointing to an active modulation of the gap junctions. 5. We hypothesize a role for coupling in the generation of the oscillatory events, providing different levels of permeability dependent on the state of conductance during the oscillatory phases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.