ArticleThe Journal of physiology1997
ATP-gated cation channels (P2X purinoceptors) in trigeminal mesencephalic nucleus neurons of the rat.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The mesencephalic trigeminal neuron: electrophysiological insights into function and dysfunction.Frontiers in cellular neuroscience · 2026Review
- Interplay between ionotropic receptors modulates inhibitory synaptic strength.Communicative & integrative biology · 2011Article
- Role of P2 purinergic receptors in synaptic transmission under normoxic and ischaemic conditions in the CA1 region of rat hippocampal slices.Purinergic signalling · 2007Article
- Biophysics of P2X receptors.Pflugers Archiv : European journal of physiology · 2006Review
- ATP modulation of excitatory synapses onto interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- ATP inhibits NMDA receptors after heterologous expression and in cultured hippocampal neurons and attenuates NMDA-mediated neurotoxicity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Membrane resonance and subthreshold membrane oscillations in mesencephalic V neurons: participants in burst generation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Single channel properties of P2X ATP receptors in outside-out patches from rat hippocampal granule cells.The Journal of physiology · 2000Article
- Allosteric control of gating and kinetics at P2X(4) receptor channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Hyperpolarization-activated cationic currents (Ih) in neurones of the trigeminal mesencephalic nucleus of the rat.The Journal of physiology · 1998Article
- Nucleotide receptors in the nervous system. An abundant component using diverse transduction mechanisms.Molecular neurobiology · 1997Review
- The selectivity of the hair cell's mechanoelectrical-transduction channel promotes Ca2+ flux at low Ca2+ concentrations.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. We have investigated whether receptors for ATP exist on neurones of the trigeminal mesencephalic nucleus (MNV) of the rat using whole-cell and outside-out patch-clamp recording in coronal brainstem slices. 2. With whole-cell recording, the batch application of ATP, adenosine 5'-O-[3-thiotriphosphate] (ATP gamma S) and alpha,beta methylene adenosine triphosphate (alpha beta meATP) caused concentration-dependent inward currents in all cells tested (holding potential, -62 mV), with EC50 values of 437, 15 and 254 microM, respectively. All three agonist-evoked currents developed rapidly (rise time, approximately 10-25 s), desensitized slowly (over approximately 20-50 s), cross-desensitized with each other, were associated with an increase in membrane conductance and were attenuated by the application of suramin (30 microM). 3. The inward current evoked by ATP decreased as the membrane potential was made less negative and had a zero current potential of +1.0 +/- 3.7 mV. The current-voltage relationship showed marked inward rectification. 4. Brief flickery single-channel openings could be resolved in response to ATP (3 microM) in outside-out membrane patches. Unitary current at -82 mV was -1.81 +/- 0.2 pA, which corresponds to a unitary conductance of 22 pS. 5. We conclude that proprioceptive MNV neurones contain ATP-gated cation channels. Such P2X purinoceptors may be involved in the processing of proprioceptive information, thus suggesting a potentially important physiological role of ATP.
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