Trial reportJournal of general internal medicine1997
Presentations of acute myocardial infarction in men and women.
Trial report in Journal of general internal medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005701 (Acute Cardiac Ischemia in Women in the ACI/TIPI Trial), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acute Cardiac Ischemia in Women in the ACI/TIPI Trial
Who cites it
25 citing papers in PubMed, 111 citations in OpenAlex.
- Referrals in acute coronary events for CARdiac catheterization: The RACE CAR trial.The Canadian journal of cardiology · 2010Trial
- Detection of exercise-induced myocardial ischemia from symptomatology experienced during testing in men and women.The Canadian journal of cardiology · 2006Trial
- Sex-specific angiographic findings and clinical features in patients with myocardial infarction.Scientific reports · 2025Article
- Extracellular vesicles: molecular messengers and new therapeutic targets in acute myocardial infarction.Frontiers in immunology · 2025Review
- Sex-Gender Differences Are Completely Neglected in Treatments for Neuropathic Pain.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Gender-based research underscores sex differences in biological processes, clinical disorders and pharmacological interventions.Biochemical pharmacology · 2023Review
- Life's Essential 8, Genetic Susceptibility, and Incident Cardiovascular Disease: A Prospective Study.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- Review
- Observational
- Observational
- Perceptions of chest pain and healthcare seeking behavior for chest pain in northern Tanzania: A community-based survey.PloS one · 2019Article
- Epidemiological Profile of Hispanics Admitted With Acute Myocardial Infarction in Puerto Rico: The Experience of 2007, 2009 and 2011.Journal of clinical medicine research · 2017Article
- Ideal Cardiovascular Health and Incident Cardiovascular Events: The Jackson Heart Study.American journal of preventive medicine · 2016Observational
- Effect of gender difference in management of heart failure patients in aseer, saudi arabia.Heart views : the official journal of the Gulf Heart Association · 2011Article
- Race/ethnic and sex differences in large and small artery elasticity--results of the multi-ethnic study of atherosclerosis (MESA).Ethnicity & disease · 2009Article
- Elapsed time in emergency medical services for patients with cardiac complaints: are some patients at greater risk for delay?Circulation. Cardiovascular quality and outcomes · 2009Article
- Symptoms across the continuum of acute coronary syndromes: differences between women and men.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2008Article
- Coronary artery disease in women: a review on prevention, pathophysiology, diagnosis, and treatment.Vascular health and risk management · 2006Review
- Perimenopausal and Postmenopausal Health.BMC women's health · 2004Article
- Management of congestive heart failure: a gender gap may still exist. Observations from a contemporary cohort.BMC cardiovascular disorders · 2003Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo assess the influence of gender on the likelihood of acute myocardial infarction (AMI) among emergency department (ED) patients with symptoms suggestive of acute cardiac ischemia, and to determine whether any specific presenting signs or symptoms are associated more strongly with AMI in women than in men.
designAnalysis of cohort data from a prospective clinical trial.
settingEmergency departments of 10 hospitals of varying sizes and types in the United States. PATIENTS: Patients 30 years of age or older (n = 10,525) who presented to the ED with chest pain or other symptoms suggestive of acute cardiac ischemia. MEASUREMENTS AND MAIN
resultsThe prevalence of AMI was determined for men and women, and a multivariable logistic regression model predicting AMI was developed to adjust for patients' demographic and clinical characteristics. AMI was almost twice as common in men as in women (10% vs 6%). Controlling for demographics, presenting signs and symptoms, electrocardiogram features, and hospital, male gender was a significant predictor of AMI (odds ratio [OR] 1.7; 95% confidence interval [CI] 1.4, 2.0). The gender effect was eliminated, however, among patients with ST-segment elevations on electrocardiogram (OR 1.1; 95% CI 0.7, 1.7) and among patients with signs of congestive heart failure (CHF) (OR 1.1; 95% CI 0.8, 1.5). Signs of CHF were associated with AMI among women (OR 1.9; 95% CI 1.4, 2.6) but not men (OR 1.0; 95% CI 0.8, 1.3). Among patients who presented to EDs with chest pain or other symptoms suggestive of acute cardiac ischemia, AMI was more likely in men than in women. Among women with ST-segment elevation or signs of CHF, however, AMI likelihood was similar to that in men with these characteristics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.