ArticleProceedings of the National Academy of Sciences of the United States of America1997
Multiple promoter elements differentially regulate the expression of the mouse tenascin gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Tenascin-C: A Key Regulator in Angiogenesis during Wound Healing.Biomolecules · 2022Review
- PRRX1 isoforms cooperate with FOXM1 to regulate the DNA damage response in pancreatic cancer cells.Oncogene · 2019Article
- Effects of nerve cells and adhesion molecules on nerve conduit for peripheral nerve regeneration.Journal of dental anesthesia and pain medicine · 2017Article
- Transcriptional regulation of tenascin genes.Cell adhesion & migration · 2015Review
- Tenascin-C: Form versus function.Cell adhesion & migration · 2015Review
- Transcription factor EGR1 directs tendon differentiation and promotes tendon repair.The Journal of clinical investigation · 2013Article
- Tenascins and the importance of adhesion modulation.Cold Spring Harbor perspectives in biology · 2011Review
- The transcription factor EGR1 regulates metastatic potential of v-src transformed sarcoma cells.Cellular and molecular life sciences : CMLS · 2010Article
- NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice.Neural development · 2009Article
- Regulation of the neuronal proteasome by Zif268 (Egr1).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Bromocriptine and clozapine regulate dopamine 2 receptor gene expression in the mouse striatum.Journal of molecular neuroscience : MN · 2005Article
- Ets transcription factors cooperate with Sp1 to activate the human tenascin-C promoter.Oncogene · 1999Article
- A binding site for homeodomain and Pax proteins is necessary for L1 cell adhesion molecule gene expression by Pax-6 and bone morphogenetic proteins.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- The neural restrictive silencer element can act as both a repressor and enhancer of L1 cell adhesion molecule gene expression during postnatal development.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Macrophage/Microglia regulation of astrocytic tenascin: synergistic action of transforming growth factor-beta and basic fibroblast growth factor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Tenascin (TN) is an extracellular matrix glycoprotein that is expressed in a characteristic spatiotemporal pattern during development and is up-regulated in the adult during tumorigenesis, wound healing, and nerve regeneration. In previous studies, we identified a promoter within the proximal 250 bp upstream of the mouse TN gene that contains several putative regulatory elements that are conserved among vertebrate TN genes. We have identified four different DNA elements within this promoter and show that they contribute in different ways to TN gene expression in NIH 3T3 fibroblasts, C6 glioma cells, and N2A neuroblastoma cells. These elements comprise a binding site for Krox proteins, one for nuclear factor 1, an octamer motif that binds POU-homeodomain proteins, and a novel TN control element. The nuclear factor 1 and TN control element had positive effects on TN promoter activity and formed similar DNA-protein complexes with nuclear extracts from all three cell lines. The Krox element had a negative effect on TN promoter activity in N2A cells, a positive effect in C6 cells, and no effect in NIH 3T3 cells. Two DNA binding complexes, one correlated with the negative and the other with the positive activities of the Krox element, were found to contain the protein Krox24. In cotransfection experiments, the octamer motif was required for induction of TN promoter activity by the POU-homeodomain protein Brn2 in N2A cells but was inactive in C6 cells. Consistent with these findings, N2A cells transfected with Brn2 formed octamer-binding complexes containing N-Oct3, the transcriptionally active form of Brn2, whereas complexes formed in C6 cells contained only N-Oct5A and N-Oct5B. Our results provide a striking example of the diversity of regulatory mechanisms that can be called forth by combining different promoter motifs with transcriptional activators or repressors.
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