ArticleProceedings of the National Academy of Sciences of the United States of America1997
Direct in vivo measurement of targeted binding in a human tumor xenograft.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 143 citations in OpenAlex.
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- Bioinformatic Profiling of Prognosis-Related Genes in Malignant Glioma Microenvironment.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
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- Spatial Modeling of Drug Delivery Routes for Treatment of Disseminated Ovarian Cancer.Cancer research · 2016Article
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- Quantity and accessibility for specific targeting of receptors in tumours.Scientific reports · 2014Article
- Modeling tumor microenvironments in vitro.Journal of biomechanical engineering · 2014Review
- FRAP in pharmaceutical research: practical guidelines and applications in drug delivery.Pharmaceutical research · 2014Review
- Strategies for advancing cancer nanomedicine.Nature materials · 2013Article
- A mechanistic compartmental model for total antibody uptake in tumors.Journal of theoretical biology · 2012Article
- Delivery of molecular and cellular medicine to solid tumors.Advanced drug delivery reviews · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Binding is crucial to the function of most biologically active molecules, but difficult to quantify directly in living tissue. To this end, fluorescence recovery after photobleaching was used to detect the immobilization of fluorescently labeled ligand caused by binding to receptors in vivo. Measurements of mAb affinity to target antigen within human tumor xenografts revealed a saturable binding isotherm, from which an in vivo carcinoembryonic antigen density of 0.56 nmol/g (5.0 x 10(5)/cell) and an association constant of Ka < or = 4 x 10(7) M(-1) were estimated. The present method can be adapted for in vivo studies of cell signaling, targeted drugs, gene therapy, and other processes involving receptor-ligand binding.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.