ArticleThe EMBO journal1997
In vivo selection of RNAs that localize in the nucleus.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 65 citations in OpenAlex.
- Widespread mono- and oligoadenylation direct small noncoding RNA maturation versus degradation fates.The EMBO journal · 2026Article
- High-throughput Screening of Sequence Elements Associated with RNA Localization.Computational and structural biotechnology journal · 2026Article
- Integrity of SRP RNA is ensured by La and the nuclear RNA quality control machinery.Nucleic acids research · 2014Article
- Packaging of host mY RNAs by murine leukemia virus may occur early in Y RNA biogenesis.Journal of virology · 2009Article
- The Lsm2-8 complex determines nuclear localization of the spliceosomal U6 snRNA.Nucleic acids research · 2007Article
- Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs.Molecular and cellular biology · 2005Article
- Mammalian peptidylglycine alpha-amidating monooxygenase mRNA expression can be modulated by the La autoantigen.Molecular and cellular biology · 2005Article
- RNA chaperone activity of protein components of human Ro RNPs.RNA (New York, N.Y.) · 2005Article
- The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle.Nucleic acids research · 2005Article
- CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5'-terminal oligopyrimidine mRNA metabolism.Molecular and cellular biology · 2004Article
- Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA.Nucleic acids research · 2003Article
- Article
- La protein and the trafficking of nascent RNA polymerase iii transcripts.The Journal of cell biology · 2001Review
- Reduction of target gene expression by a modified U1 snRNA.Molecular and cellular biology · 2001Article
- Fending off decay: a combinatorial approach in intact cells for identifying mRNA stability elements.RNA (New York, N.Y.) · 2001Article
- Recognition of nascent RNA by the human La antigen: conserved and divergent features of structure and function.Molecular and cellular biology · 2001Review
- Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting.The EMBO journal · 2000Article
- The matrix protein of vesicular stomatitis virus inhibits nucleocytoplasmic transport when it is in the nucleus and associated with nuclear pore complexes.Molecular and cellular biology · 2000Article
- La protein has a positive effect on the translation of TOP mRNAs in vivo.Nucleic acids research · 2000Article
- Theoretical design of antisense genes with statistically increased efficacy.Nucleic acids research · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Nuclear localization of an RNA is affected by cis-acting elements (NLEs) that lead to nuclear import or retention or to blockage of export from the nucleus. To identify such elements, we selected and analyzed transcripts that localized in the nuclei of Xenopus laevis oocytes. The RNAs were isolated from a collection of m7G-capped RNAs in which a combinatorial library (n = 20) of sequences had been inserted. One class of selected RNAs (Sm+) had a consensus Sm binding site (AAUUUUUGG) and bound Sm proteins in the cytoplasm; these RNAs resembled small nuclear RNAs like U1 and U5 RNAs in their bi-directional nucleocytoplasmic transport and their 5'-cap hypermethylation. Another class, Sm- RNAs, contained sequences that masked the m7G-caps of the RNAs and promoted interaction with La protein. These RNAs were retained within nuclei after nuclear injection and were imported when injected into the cytoplasm. Their nuclear import and retention were independent of a 5'-cap, required an imperfect double-stranded stem near the 5' end, and depended on interaction with La protein. Import of the Sm- RNAs, while using the import pathway of proteins, was distinct from that of U6 RNA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.