Evidence map›Paper›PMID 9048212›Full record

ReviewImmunologic research1997

Multiplicity of uses of monoclonal antibodies that define papillomavirus linear immunodominant epitopes.

A B Jenson, M C Jenson, L Cowsert, S J Ghim, J P Sundberg

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A B JensonDepartment of Pathology, Georgetown University School of Medicine, Washington, DC 20007, USA.
M C Jenson
L Cowsert
S J Ghim
J P Sundberg

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the last 10 yr, we have derived monoclonal antibodies from animals immunized with denatured bovine papillomaviruses type 1 major capsid (L1) protein, mapped their corresponding immunodominant epitopes to within a single amino acid (aa), and compared the reactivity of authentic L1 proteins to the predicted response by collinear analysis of the aa sequences of the same and other papillomaviruses (PVs). The data obtained from this approach has provided us with new insights into the sensitivity and specificity of the antibody response to viral proteins. We have included here some observations and conclusions that appear to be generic for the immune response, some of which might have applications for working with linear epitopes in other experimental systems.

Indexed as

Antibodies, MonoclonalEpitope MappingAmino Acid SequenceAnimalsBovine papillomavirus 1HumansImmunodominant EpitopesMolecular Sequence DataPapillomavirus InfectionsTumor Virus InfectionsAntibodies, MonoclonalImmunodominant Epitopes

Identifiers

PMID9048212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.