ArticleMolecular and cellular biochemistry1997
Identification of 45 kD antigen in immune complexes of patients of allergic bronchopulmonary aspergillosis.
Article in Molecular and cellular biochemistry, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Allergic Bronchopulmonary Aspergillosis: A Perplexing Clinical Entity.Allergy, asthma & immunology research · 2016Review
- Allergic aspergillosis of the respiratory tract.European respiratory review : an official journal of the European Respiratory Society · 2014Review
- Investigation of Aspergillus fumigatus biofilm formation by various "omics" approaches.Frontiers in microbiology · 2013Article
- Allergens/Antigens, toxins and polyketides of important Aspergillus species.Indian journal of clinical biochemistry : IJCB · 2011Article
- Expression and characterization of Asp fI, an immunodominant allergen/antigen of A. fumigatus in insect cell.Molecular and cellular biochemistry · 2003Article
- Host pathogen interactions in allergic and invasive fungal diseases: Diagnostic and therapeutic implications.Indian journal of clinical biochemistry : IJCB · 2001Article
- Challenges in prevention, diagnosis and therapy of emerging fungal diseases. Aspergillosis: A case study.Indian journal of clinical biochemistry : IJCB · 2000Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A glycoprotein antigen with an apparent mw of 45 kD was observed to be predominant in the circulating immune complexes isolated from patients of allergic bronchopulmonary aspergillosis as well as in the immune complexes prepared in vitro. Further characterisation of 45 kD antigen with trypsin showed four immunologically active peptides with mw 43, 36, 33 and 16 kD. Carbohydrate characterization using various lectins (Maackia amurensis agglutinin, Sambucus nigra agglutinin, Peanut agglutinin, Galanthus nivalis agglutinin and Datura stramonium agglutinin) showed presence of both N-linked and O-linked sugar moieties such as mannose, glucose, galactose and N-acetyl glucosamine. Predominant presence of 45 kD antigen in immune complexes, recognition of 45 kD by monoclonal antibodies raised against glycoprotein rich fraction of A. fumigatus and presence of elastinolytic protease activity indicate that 45 kD antigen is probably a potent virulence factor and may be contributing to the pathogenesis of ABPA by its biological as well as immunological activities.
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