ArticleJapanese journal of cancer research : Gann1997
Stromal expression of MMP-9 and urokinase receptor is inversely associated with liver metastasis and with infiltrating growth in human colorectal cancer: a novel approach from immune/inflammatory aspect.
Article in Japanese journal of cancer research : Gann, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- The Role of MMP8 in Cancer: A Systematic Review.International journal of molecular sciences · 2019Pooled it
- MMP-9-dependent proteolysis of the histone H3 N-terminal tail: a critical epigenetic step in driving oncogenic transcription and colon tumorigenesis.Molecular oncology · 2024Article
- Quantitative Proteomics Analysis of Sporadic Medullary Thyroid Cancer Reveals FN1 as a Potential Novel Candidate Prognostic Biomarker.The oncologist · 2018Article
- Influence of Immune Myeloid Cells on the Extracellular Matrix During Cancer Metastasis.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2016Review
- WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.The Journal of clinical investigation · 2015Article
- The regulation of MMP targeting to invadopodia during cancer metastasis.Frontiers in cell and developmental biology · 2015Review
- Article
- Lack of MMP-9 expression is a marker for poor prognosis in Dukes' B colorectal cancer.BMC clinical pathology · 2012Article
- Inhibition of stathmin1 accelerates the metastatic process.Cancer research · 2012Article
- Genetic polymorphisms in MMP 2, 9 and 3 genes modify lung cancer risk and survival.BMC cancer · 2012Article
- Protein kinase D1 inhibits cell proliferation through matrix metalloproteinase-2 and matrix metalloproteinase-9 secretion in prostate cancer.Cancer research · 2010Article
- MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not.British journal of cancer · 2008Article
- Integrin alpha v beta 6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver.Cancer science · 2008Article
- Clinicopathological significance of stromal variables: angiogenesis, lymphangiogenesis, inflammatory infiltration, MMP and PINCH in colorectal carcinomas.Molecular cancer · 2006Review
- Tissue levels of active matrix metalloproteinase-2 and -9 in colorectal cancer.British journal of cancer · 2002Article
- Overexpression of matrix-metalloproteinase-9 in human breast cancer: a potential favourable indicator in node-negative patients.British journal of cancer · 2001Article
- The clinical significance of MMP-1 expression in oesophageal carcinoma.British journal of cancer · 2001Article
- Cell surface molecules and their prognostic values in assessing colorectal carcinomas.Annals of surgery · 2000Review
- Expression of globo-series gangliosides in human renal cell carcinoma.Japanese journal of cancer research : Gann · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MMP-9 (gelatinase B) and urokinase-type plasminogen activator receptor (u-PAR), which are involved in cancer cell invasion and metastasis, are reported to be predominantly expressed by immune/inflammatory cells in human colorectal cancers. To investigate their significance in cancer progression, we morphometrically analyzed the tissue expression of MMP-9 and u-PAR among different stages of colorectal cancer. The numbers of MMP-9- and u-PAR-positive cells along the invasive margin were significantly smaller in cases with liver metastasis than in cases without liver metastasis, and were also smaller in cases with an infiltrating margin than in cases with an expanding margin. Both variables were larger in colon cancer cases with conspicuous lymphocytic infiltration. These results indicated that the degree of tissue expression of MMP-9 and u-PAR by host cells is inversely associated with liver metastasis and an infiltrating growth pattern in human colorectal cancers. Essentially the same results were obtained for the number of macrophages distributed along the invasive margin. We also found that the expression pattern of MMP-9 was similar to that of MMP-8 (polymorphonuclear leukocyte collagenase). These data are consistent with clinicopathologic studies of host cells. Therefore, our data suggest a dual role of MMP-9 and u-PAR expression in colon cancer tissue; i.e., not only are these proteinases cancer-promoting factors, but also they are related to the host defensive mechanism when they are expressed by host cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.