ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Synchrony of clonal cell proliferation and contiguity of clonally related cells: production of mosaicism in the ventricular zone of developing mouse neocortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 63 citations in OpenAlex.
- cytoNet: Spatiotemporal network analysis of cell communities.PLoS computational biology · 2022Article
- Multicolor lineage tracing using in vivo time-lapse imaging reveals coordinated death of clonally related cells in the developing vertebrate brain.Developmental biology · 2019Article
- Huntington Disease as a Neurodevelopmental Disorder and Early Signs of the Disease in Stem Cells.Molecular neurobiology · 2018Review
- Transcriptional and Post-Transcriptional Mechanisms of the Development of Neocortical Lamination.Frontiers in neuroanatomy · 2017Review
- Article
- Subset of early radial glial progenitors that contribute to the development of callosal neurons is absent from avian brain.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Neural stem cells could serve as a therapeutic material for age-related neurodegenerative diseases.World journal of stem cells · 2015Review
- Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia.Human molecular genetics · 2009Article
- Gap junctions modulate interkinetic nuclear movement in retinal progenitor cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- The Tlx gene regulates the timing of neurogenesis in the cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Mitotic spindle rotation and mode of cell division in the developing telencephalon.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Article
- Expression of the antiproliferative gene TIS21 at the onset of neurogenesis identifies single neuroepithelial cells that switch from proliferative to neuron-generating division.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Patterns of intracellular calcium fluctuation in precursor cells of the neocortical ventricular zone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Changes in cell-cycle kinetics during the development and evolution of primate neocortex.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Cell coupling and uncoupling in the ventricular zone of developing neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Local homogeneity of cell cycle length in developing mouse cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Reactive invagination of the neuroepithelium in the rudiments of the neocortex, tectum of the midbrain, and retina of the eye in humans at different stages of development.Neuroscience and behavioral physiologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have analyzed clonal cell proliferation in the ventricular zone (VZ) of the early developing mouse neocortex with a replication-incompetent retrovirus encoding human placental alkaline phosphatase (AP). The retrovirus was injected into the lateral ventricles on embryonic day 11 (E11), i.e., at the onset of neuronogenesis. Three days postinjection, on E14, a total of 259 AP-labeled clones of various sizes were found in 7 fetal brains. There are approximately 7 cell cycles between E11 and E14 (), and there is a 1-2 cell cycle delay between retroviral injection and the production of a retrovirally labeled "founder" cell; thus, we estimate that the "age" of the clones was about 5-6 cell cycles. Almost one-half of the clones (48.3%) identified were pure proliferating clones containing cells only in the VZ. Another 18.5% contained both proliferating and postproliferative cells, and 33.2% contained only postproliferative cells. It was striking that over 90% of the clonally related proliferating cells occurred in clusters of two or more apparently contiguous cells, and about 73% of the proliferating cells occurred in clusters of three or more cells. Regardless of the number of cells in the clone, these clusters were tightly packed and confined to a single level of the VZ. This clustering of proliferating cells indicates that clonally related cells maintain neighbor-neighbor relationships as they undergo interkinetic nuclear migration and progress through several cell cycles, and, as a result, the ventricular zone is a mosaic of small clusters of clonally related and synchronously cycling cells. In addition, cells in the intermediate zone and the cortical plate were also frequently clustered, indicating that they became postproliferative at a similar time and that the output of the VZ is influenced by its mosaic structure.
Indexed as
Identifiers
9045736PMC6793751W2118263629What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.