ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Local homogeneity of cell cycle length in developing mouse cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The trial behind it
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Who cites it
28 citing papers in PubMed, 85 citations in OpenAlex.
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- RGCC balances self-renewal and neuronal differentiation of neural stem cells in the developing mammalian neocortex.EMBO reports · 2021Article
- Mechanisms of radial glia progenitor cell lineage progression.FEBS letters · 2017Review
- Pax6 controls centriole maturation in cortical progenitors through Odf2.Cellular and molecular life sciences : CMLS · 2015Article
- Cell cycle and lineage progression of neural progenitors in the ventricular-subventricular zones of adult mice.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation.Neural development · 2012Article
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- Heterogeneity in ventricular zone neural precursors contributes to neuronal fate diversity in the postnatal neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Seizures increase cell proliferation in the dentate gyrus by shortening progenitor cell-cycle length.Epilepsia · 2009Article
- Article
- Gap junctions modulate interkinetic nuclear movement in retinal progenitor cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Selective lengthening of the cell cycle in the neurogenic subpopulation of neural progenitor cells during mouse brain development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- The Tlx gene regulates the timing of neurogenesis in the cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Mitotic spindle rotation and mode of cell division in the developing telencephalon.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Cell contact regulates fate choice by cortical stem cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Separate proliferation kinetics of fibroblast growth factor-responsive and epidermal growth factor-responsive neural stem cells within the embryonic forebrain germinal zone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We have measured the amount of variation in the length of the cell cycle for cells in the pseudostratified ventricular epithelium (PVE) of the developing cortex of mice on embryonic day 14. Our measurements were made in three cortical regions (i.e., the neocortex, archicortex, and periarchicortex) using three different methods: the cumulative labeling method (CLM), the percent labeled mitoses (PLM) method, and a comparison of the time needed for the PLM to ascend from 0 to 100% with the time needed for the PLM to descend from 100 to 0%. These 3 different techniques provide different perspectives on the cytokinetic parameters. Theoretically, CLM gives an estimate for a maximum value of the total length of the cell cycle (TC), whereas PLM gives an estimate of a minimum value of TC. The difference between these two estimates indicates that the range for TC is +/-1% of the mean TC for periarchicortex, +/-7% for neocortex, and +/-8% for archicortex. This was confirmed by a lengthening of the PLM descent time in comparison with its ascent time. The sharpness of the transitions and the flatness of the plateau of the PLM curves indicate that 99% of the proliferating cells are within this narrow estimated range for TC; hence, only approximately 1% deviate outside of a relatively restricted range from the average TC of the population. In the context of the possible existence within the cortical PVE of two populations with markedly dissimilar cell cycle kinetics from the mean, one such population must comprise approximately 99% of the total population, and the other, if it exists, is only approximately 1% of the total. This seems to be true for all three cortical regions. The narrow range of TC indicates a homogeneity in the cell cycle length for proliferating cells in three different cortical regions, despite the fact that progenitor cells of different lineages may be present. It further predicts the existence of almost synchronous interkinetic nuclear movements of the proliferating cells in the ventricular zone during early development of the cerebral cortex.
Indexed as
Identifiers
9045735PMC6793765W1919729993What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.