ArticleAmerican journal of human genetics1997
The age dependency of gene expression for plasma lipids, lipoproteins, and apolipoproteins.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program.Atherosclerosis · 2014Pooled it
- Genetic architecture of lipid traits changes over time and differs by race: Princeton Lipid Follow-up Study.Journal of lipid research · 2014Trial
- Enigma of Twins: Identical Presentation and Angiographic Lesion in Monozygotic Twins.Journal of the Saudi Heart Association · 2022Article
- Genetic Risk Scores for Complex Disease Traits in Youth.Circulation. Genomic and precision medicine · 2020Article
- Heritable traits that contribute to nephrolithiasis.Urolithiasis · 2019Review
- Heritability and Genome-Wide Association Study of Plasma Cholesterol in Chinese Adult Twins.Frontiers in endocrinology · 2018Article
- Methods to evaluate rare variants gene-age interaction for triglycerides.BMC proceedings · 2018Article
- FADS1-FADS2 gene cluster confers risk to polycystic ovary syndrome.Scientific reports · 2016Article
- Rationale, Design, and Methodological Aspects of the BUDAPEST-GLOBAL Study (Burden of Atherosclerotic Plaques Study in Twins-Genetic Loci and the Burden of Atherosclerotic Lesions).Clinical cardiology · 2015Article
- Non-identical yet similar: presentation of coronary artery disease in dizygotic twins.Cardiovascular diagnosis and therapy · 2015Article
- Gene-Gene Interactions among Pparα/δ/γ Polymorphisms for Apolipoprotein (Apo) A-I/Apob Ratio in Chinese Han Population.Iranian journal of public health · 2014Article
- Heritability of metabolic syndrome traits in a large population-based sample.Journal of lipid research · 2013Article
- Post-genome-wide association study challenges for lipid traits: describing age as a modifier of gene-lipid associations in the Population Architecture using Genomics and Epidemiology (PAGE) study.Annals of human genetics · 2013Article
- The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2013Article
- Evidence of differential allelic effects between adolescents and adults for plasma high-density lipoprotein.PloS one · 2012Article
- Evidence for age as a modifier of genetic associations for lipid levels.Annals of human genetics · 2011Article
- Cholesteryl ester transfer protein gene polymorphisms and longevity syndrome.The open cardiovascular medicine journal · 2010Article
- Heritability of serum apolipoprotein concentrations in middle-aged Japanese twins.Journal of epidemiology · 2009Article
- Genetics of hemostasis: differential effects of heritability and household components influencing lipid concentrations and clotting factor levels in 282 pediatric stroke families.Environmental health perspectives · 2008Article
- Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: heritabilities.Diabetologia · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate and disentangle the genetic and nongenetic causes of stability and change in lipids and (apo)lipoproteins that occur during the lifespan. Total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), and lipoprotein(a) (Lp[a]) were measured in a group of 160 middle-aged parents and their twin offspring (first project) and in a group of 203 middle-aged twin pairs (second project). Combining the data of both projects enabled the estimation of the extent to which measured lipid parameters are influenced by different genes in adolescence and adulthood. To that end, an extended quantitative genetic model was specified, which allowed the estimation of heritabilities for each sex and generation separately. Heritabilities were similar for both sexes and both generations. Larger variances in the parental generation could be ascribed to proportional increases in both unique environmental and additive genetic variance from childhood to adulthood, which led to similar heritability estimates in adolescent and middle-aged twins. Although the magnitudes of heritabilities were similar across generations, results showed that, for total cholesterol, triglycerides, HDL, and LDL, partly different genes are expressed in adolescence compared to adulthood. For triglycerides, only 46% of the genetic variance was common to both age groups; for total cholesterol this was 80%. Intermediate values were found for HDL (66%) and LDL (76%). For ApoA1, ApoB, and Lp(a), the same genes seem to act in both generations.
Indexed as
Identifiers
9042925PMC1712506What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.