ArticleJournal of clinical pathology1996
Ki-67 expression in early prostate cancer and associated pathological lesions.
Article in Journal of clinical pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 73 citations in OpenAlex.
- Exploring the Link Between Obligate Anaerobe-Related Dysbiosis and Prostate Cancer Development: A Pilot Study.Cancers · 2024Article
- Synthesis of novel 4-Boc-piperidone chalcones and evaluation of their cytotoxic activity against highly-metastatic cancer cells.Bioorganic & medicinal chemistry letters · 2020Article
- Telomeres and telomerase in prostate cancer development and therapy.Nature reviews. Urology · 2017Review
- Survival analysis of patients with biochemical relapse after radical prostatectomy treated with androgen deprivation: Castration-resistance influential factors.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2014Article
- The role of metabolic imaging in radiation therapy of prostate cancer.NMR in biomedicine · 2014Review
- Inflammation and preneoplastic lesions in benign prostate as risk factors for prostate cancer.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2012Article
- Correlation of phospholipid metabolites with prostate cancer pathologic grade, proliferative status and surgical stage - impact of tissue environment.NMR in biomedicine · 2011Article
- Ki-67 and outcome in clinically localised prostate cancer: analysis of conservatively treated prostate cancer patients from the Trans-Atlantic Prostate Group study.British journal of cancer · 2009Article
- Inflammation in prostate carcinogenesis.Nature reviews. Cancer · 2007Review
- Intermediate cells in human prostate epithelium are enriched in proliferative inflammatory atrophy.The American journal of pathology · 2003Article
- Immunopathological prognostic and predictive factors in prostate cancer.International urology and nephrology · 2002Review
- Clinical and experimental progression of a new model of human prostate cancer and therapeutic approach.The American journal of pathology · 2001Article
- Postatrophic hyperplasia of the prostate gland: neoplastic precursor or innocent bystander?The American journal of pathology · 2001Article
- Does screening for prostate cancer identify clinically important disease?Annals of the Royal College of Surgeons of England · 1999Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess cell proliferation in early prostate cancer and associated pathological lesions.
methodsUsing the Ki-67 antibody, the cell proliferation index was measured in early stage prostatic carcinoma in 37 incidental tumours diagnosed at transurethral prostatectomy (TURP) and in 20 low volume cancers treated by radical prostatectomy. Proliferation indexes have also been measured in areas of normal peripheral zone, transition zone hyperplasia, atrophic appearing lobules, and high grade prostatic intraepithelial neoplasia in the radical prostatectomy cases.
resultsIn the TURP series the proliferation index correlated with grade and stage. Logistic regression analysis, however, showed that Gleason grade was the most reliable predictor of biopsy proven residual disease and clinical progression. In the radical series transition zone carcinoma the proliferation index was half that of peripheral zone carcinoma. The atrophic lobules also showed a high proliferation index of the same order as seen in the peripheral zone carcinoma. Normal peripheral zone showed the lowest proliferation index and in hyperplastic transition zone it was also less than the other areas.
conclusionsThere is only limited support for the correlation of proliferation index with grade in early stage prostatic carcinoma. The findings do not suggest that proliferation index adds to the prognostic information given by grade and stage in pT1 disease. The significant difference in proliferation index in transition zone and peripheral zone carcinomas supports the morphological distinction of these tumour types and is consistent with differences in biological behaviour. The high proliferation index in lobules considered morphologically atrophic is reminiscent of previous observations in which carcinoma was spatially associated with atrophy.
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