ArticleJournal of clinical pathology1996
p53 expression in carcinoma of the cervix.
Article in Journal of clinical pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Proteomic Analysis of TCGA Data Reveals Limited Prognostic Value of p53 but Suggests BAX as a Potential Survival Marker in Cervical Carcinoma.International journal of molecular sciences · 2026Article
- The Role of p53 Gene in Cervical Carcinogenesis.Journal of obstetrics and gynaecology of India · 2016Article
- Immunophenotype and human papillomavirus status of serous adenocarcinoma of the uterine cervix.Pathology oncology research : POR · 2015Article
- Expression of E6, p53 and p21 proteins and physical state of HPV16 in cervical cytologies with and without low grade lesions.International journal of clinical and experimental medicine · 2014Article
- Expression of cyclins, p53, and Ki-67 in cervical squamous cell carcinomas: overexpression of cyclin A is a poor prognostic factor in stage Ib and II disease.Virchows Archiv : an international journal of pathology · 2005Article
- p53 immunohistochemical expression of Egyptian cervical carcinoma.Pathology oncology research : POR · 1999Article
- Prognostic significance of the bcl-2 apoptotic family of proteins in primary and recurrent cervical cancer.British journal of cancer · 1998Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess overexpression of the proposed tumour suppressor gene product p53 using the mouse monoclonal antibody DO-7 in the three main subtypes of carcinoma of the uterine cervix and to evaluate its value as a prognostic indicator.
methodsEighty two cases of FIGO Stage IB/IIA uterine cervical carcinoma were studied retrospectively. The tumours had been previously typed into adenocarcinomas, squamous carcinomas and adenosquamous carcinomas after the tissue had been fixed in formalin and embedded in paraffin wax. p53 protein expression was assessed using a standard immunohistochemical technique and the findings were correlated with tumour type, lymph node status and clinical outcome.
resultsIn total, the p53 gene product was overexpressed in 17.1% (14/82) of all carcinomas and also in areas of cervical intraepithelial neoplasia grade III adjacent to invasive squamous carcinoma. Where present, the normal epithelium was uniformly negative. No association was found between p53 overexpression and tumour subtype, lymph node status or clinical outcome.
conclusionsIt seems unlikely that p53 analysis will be of value in determining prognosis in carcinoma of the uterine cervix.
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