ArticleGut1996
Increased production of interleukin 1 beta and hepatocyte growth factor may contribute to foveolar hyperplasia in enlarged fold gastritis.
Article in Gut, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 82 citations in OpenAlex.
- Effect of drug treatment on hyperplastic gastric polyps infected with Helicobacter pylori: a randomized, controlled trial.World journal of gastroenterology · 2006Trial
- Review
- [Clinical Application of the Kyoto Classification of Gastritis].The Korean journal of helicobacter and upper gastrointestinal research · 2023Review
- Helicobacter pylori eradication reduces risk for recurrence of gastric hyperplastic polyp after endoscopic resection.The Korean journal of internal medicine · 2023Article
- Regression of gastric endoscopic submucosal dissection induced polypoid nodular scar afterWorld journal of clinical cases · 2022Article
- Consistency between the endoscopic Kyoto classification and pathological updated Sydney system for gastritis: A cross-sectional study.Journal of gastroenterology and hepatology · 2022Article
- Enlarged folds on endoscopic gastritis as a predictor for submucosal invasion of gastric cancers.World journal of gastrointestinal endoscopy · 2021Article
- Endoscopic Characteristics of Rugal Hyperplasia and Related Acid Condition in Helicobacter pylori-Infected Stomach.Clinical endoscopy · 2021Article
- Endoscopic Kyoto classification ofWorld journal of gastroenterology · 2020Review
- A Rare Case of Hypertrophic Gastropathy with Adenocarcinoma Arising from a Gastric-type Adenoma.Internal medicine (Tokyo, Japan) · 2019Article
- Nodular gastritis in association with gastric cancer development before and afterJGH open : an open access journal of gastroenterology and hepatology · 2018Article
- Interleukin-1B signalling leads to increased survival of gastric carcinoma cells through a CREB-C/EBPβ-associated mechanism.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016Article
- Gastric inflammatory fibroid polyp morphologically changed by Helicobacter pylori eradication.Clinical journal of gastroenterology · 2015Article
- Unusual Manifestation of Gastric Helicobacter pylori Infection.Case reports in gastroenterology · 2012Article
- Advanced gastric cancer associated with nodular gastritis in a young patient.Clinical journal of gastroenterology · 2009Article
- Characteristic pathological findings and effects of ecabet sodium in rat reflux esophagitis.World journal of gastroenterology · 2009Article
- NSAID-induced antral ulcers are associated with distinct changes in mucosal gene expression.Alimentary pharmacology & therapeutics · 2009Article
- Helicobacter pylori isolated from a patient with Ménétrier's disease increases hepatocyte growth factor mRNA expression in gastric fibroblasts: comparison with Helicobacter pylori isolated from other gastric diseases.Digestive diseases and sciences · 2008Article
- Cytomegalovirus and Helicobacter pylori co-infection in a child with Ménétrier disease.European journal of pediatrics · 2007Article
- Causal role of Helicobacter pylori infection and eradication therapy in gastric carcinogenesis.World journal of gastroenterology · 2006Review
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsIt has been reported that eradication of Helicobacter pylori improves fold width in H pylori associated enlarged fold gastritis. The aim of this study was to clarify the mechanism of fold thickening in this condition. PATIENTS AND
methodsIn eight patients with enlarged fold gastritis and 13 patients without enlarged folds, the presence of H pylori infection, inflammatory infiltrates, mucosal plasia, and epithelial cell proliferation in the body mucosa were investigated, and production of transforming growth factor alpha (TGF alpha), hepatocyte growth factor (HGF), and interleukin 1 beta (IL 1 beta) was determined by a competitive reverse transcription/polymerase chain reaction method and in vitro short-term culture of biopsy specimens.
resultsIn the patients with enlarged fold gastritis, inflammatory infiltrates including macrophages increased with H pylori colonisation in the body. Foveolar thickness and proliferating cell nuclear antigen (PCNA) labelling index were increased. Messenger RNA levels of HGF, but not TGF alpha, were increased, and release of HGF and IL 1 beta was increased. HGF release, which was positively correlated with IL 1 beta release and foveolar thickness, decreased in the presence of IL 1 receptor antagonist. After eradication of H pylori, inflammatory infiltrates, IL 1 beta and HGF release decreased with concomitant decreases in PCNA labelling index, foveolar thickness and fold width.
conclusionsIncreased IL 1 beta and HGF production caused by H pylori infection may contribute to fold thickening of the stomach by stimulating epithelial cell proliferation and foveolar hyperplasia in patients with enlarged fold gastritis.
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